What are the most valued startups in the longevity biotech market?

Last updated: 13 July 2026

market research pitch 2026

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The longevity biotech market includes companies developing therapies, diagnostics, research platforms, and healthcare services designed to extend healthy human lifespan.

This ranking compares the latest reported or estimated valuations of longevity biotech startups, and we update the list every month.

The dataset shows a highly concentrated market, with a small group of cellular rejuvenation and drug discovery companies accounting for most of the sector's estimated value.

A quick summary table

Metric Value
Most valuable longevity biotech startup Altos Labs, $10.0B–$50.0B
Second most valuable longevity biotech startup BioSplice Therapeutics, $8.0B–$12.0B
Median longevity biotech valuation Approximately $45M
Share of longevity biotech value captured by the top 10 Approximately 88.2%
Top longevity biotech valuation vs. median Approximately 667 times, using valuation midpoints
Median longevity biotech valuation-to-capital-raised ratio Approximately 3.5 times
Longevity biotech startups valued at $1B+ 8

Top startups in the longevity biotech market ranked by valuation

Here is an updated table that ranks the top startups in the longevity biotech market based on their latest reported or estimated valuations.

# Startup Name What They Do Current Valuation ($) Valuation Confidence Level Valuation Type Evidence Status Total Funding ($) Funding Confidence Level
1 Altos Labs Cellular rejuvenation therapies $10.0B–$50.0B Low Confidence Proxy-Based Estimate Estimated $3.0B Full Confidence
2 BioSplice Therapeutics Alternative splicing therapeutics $8.0B–$12.0B Partial Confidence Comparables-Based Estimate Estimated $778M Strong Confidence
3 Calico Aging biology and therapeutics research $2.5B–$4.0B Partial Confidence Comparables-Based Estimate Estimated Undisclosed Low Confidence
4 NewLimit Epigenetic cell reprogramming $3.1B Full Confidence Announced Private Round Valuation Observed $715M Strong Confidence
5 Insilico Medicine AI drug discovery $2.6B Full Confidence Public Market Cap Observed $811M Partial Confidence
6 Retro Biosciences Healthspan extension therapeutics $1.8B Strong Confidence Announced Private Round Valuation Observed $180M Partial Confidence
7 BioAge Labs Metabolic aging therapeutics $1.0B Full Confidence Public Market Cap Observed $492M Strong Confidence
8 Loyal Dog longevity medicines $800M–$1.2B Strong Confidence Implied Valuation from Raise Implied $250M Partial Confidence
9 Cambrian Bio Healthspan biotech portfolio $600M–$900M Partial Confidence Implied Valuation from Raise Estimated $160M Full Confidence
10 Life Biosciences Cellular rejuvenation therapies $500M–$900M Strong Confidence Implied Valuation from Raise Implied $237M Strong Confidence
11 Nura Bio Neuroprotective SARM1 inhibitor drugs $500M–$800M Strong Confidence Implied Valuation from Raise Implied $215M Full Confidence
12 Aeovian Pharmaceuticals Selective mTORC1 inhibitor drugs $400M–$650M Strong Confidence Implied Valuation from Raise Implied $142M Full Confidence
13 Alzheon Alzheimer’s oral therapeutics $300M–$600M Partial Confidence Comparables-Based Estimate Estimated $160M Partial Confidence
14 Rejuveron Life Sciences Healthy-aging therapeutics portfolio $300M–$500M Partial Confidence Implied Valuation from Raise Estimated $76M Partial Confidence
15 Human Longevity Genomics health intelligence $250M–$310M Partial Confidence Proxy-Based Estimate Estimated $330M Partial Confidence
16 Juvena Therapeutics AI-designed regenerative biologics $225M–$350M Strong Confidence Implied Valuation from Raise Implied $84M Strong Confidence
17 Navitor Pharmaceuticals mTORC1-targeted neurological therapeutics $150M–$350M Partial Confidence Acquisition Value Observed $72M Strong Confidence
18 Rubedo Life Sciences Senescent-cell targeted therapeutics $180M–$300M Partial Confidence Implied Valuation from Raise Estimated $52M Full Confidence
19 Jocasta Neuroscience Klotho therapies for cognitive decline $175M–$290M Strong Confidence Implied Valuation from Raise Implied $35M Full Confidence
20 MindImmune Therapeutics Neuroinflammation Alzheimer’s therapeutics $150M–$230M Strong Confidence Implied Valuation from Raise Implied $31M Strong Confidence
21 Amplifier Therapeutics AMPK metabolic disease therapeutics $140M–$230M Partial Confidence Implied Valuation from Raise Estimated $38M Partial Confidence
22 Turn Biotechnologies mRNA cellular rejuvenation therapies $140M–$220M Partial Confidence Comparables-Based Estimate Estimated $30M Partial Confidence
23 Gordian Biotechnology In-vivo aging drug discovery $150M–$210M Partial Confidence Comparables-Based Estimate Estimated $60M Partial Confidence
24 resTORbio Aging-related mTOR therapeutics $170M Full Confidence Acquisition Value Observed $163M Full Confidence
25 Elevian Regenerative GDF11-based medicines $120M–$200M Low Confidence Comparables-Based Estimate Estimated $61M Full Confidence
26 Gero AI aging drug discovery $120M–$180M Strong Confidence Implied Valuation from Raise Implied $34M Partial Confidence
27 Proteostasis Therapeutics Protein-homeostasis therapeutics $150M Strong Confidence Acquisition Value Observed $235M Strong Confidence
28 Alkahest Plasma-proteome aging therapeutics $146M Strong Confidence Acquisition Value Observed $41M Strong Confidence
29 Thymmune Therapeutics Regenerative thymic cell therapies $140M Full Confidence Acquisition Value Observed $7M Full Confidence
30 Mitotech Mitochondria-targeted small molecules $90M–$180M Low Confidence Comparables-Based Estimate Estimated $43M Low Confidence
31 Arda Therapeutics Pathogenic-cell depletion therapies $70M–$110M Strong Confidence Announced Private Round Valuation Estimated $43M Full Confidence
32 Samsara Therapeutics Autophagy drugs for neurodegeneration $75M–$125M Partial Confidence Comparables-Based Estimate Estimated $28M Partial Confidence
33 Tolerance Bio Thymus immune-tolerance therapies $80M–$120M Strong Confidence Implied Valuation from Raise Implied $35M Strong Confidence
34 LyGenesis Lymph-node organ regeneration $75M–$115M Partial Confidence Comparables-Based Estimate Estimated $22M Strong Confidence
35 Spring Discovery AI-enabled biological research platform $60M–$120M Partial Confidence Acquisition Value Estimated $48M Partial Confidence
36 Oisin Biotechnologies Genetic senolytic aging therapies $65M–$105M Partial Confidence Implied Valuation from Raise Estimated $15M Low Confidence
37 Repair Biotechnologies Cholesterol-degrading genetic therapies $70M–$85M Strong Confidence Implied Valuation from Raise Implied $26M Partial Confidence
38 Rejuvenate Biomed Sarcopenia drug development $55M–$95M Partial Confidence Comparables-Based Estimate Estimated $22M Strong Confidence
39 Booster Therapeutics Proteasome-activating medicines $60M–$90M Partial Confidence Implied Valuation from Raise Implied $15M Full Confidence
40 Circulate Health Therapeutic plasma-exchange longevity care $55M–$80M Strong Confidence Implied Valuation from Raise Implied $12M Full Confidence
41 Shift Bioscience AI cellular rejuvenation discovery $65M–$110M Partial Confidence Implied Valuation from Raise Estimated $29M Partial Confidence
42 Generation Lab Biological-aging diagnostic platform $50M–$75M Strong Confidence Implied Valuation from Raise Implied $15M Strong Confidence
43 Rejuvenate Bio Gene therapies for age-related diseases $59M Strong Confidence Active Raise Valuation Observed $16M Strong Confidence
44 GlycanAge Glycan biological-age testing $45M–$70M Strong Confidence Implied Valuation from Raise Implied $13M Strong Confidence
45 Junevity siRNA cellular-reprogramming therapies $45M–$65M Strong Confidence Implied Valuation from Raise Implied $20M Full Confidence
46 Epiterna Aging-focused drug discovery $40M–$60M Partial Confidence Implied Valuation from Raise Estimated $11M Strong Confidence
47 MitoRx Therapeutics Mitochondrial metabolic-disease therapeutics $36M–$55M Strong Confidence Implied Valuation from Raise Implied $12M Strong Confidence
48 Rejuvenation Technologies Telomere-extending mRNA therapeutics $35M–$55M Partial Confidence Implied Valuation from Raise Estimated $11M Partial Confidence
49 Deciduous Therapeutics Senescent-cell immune therapies $35M–$55M Low Confidence Comparables-Based Estimate Estimated $17M Partial Confidence
50 NaNotics Subtractive nanoparticle therapeutics $30M–$50M Low Confidence Comparables-Based Estimate Estimated $10M Partial Confidence
51 Cyclarity Therapeutics Toxic-cholesterol disease therapeutics $32M–$42M Strong Confidence Announced Private Round Valuation Estimated $24M Strong Confidence
52 Matter Bio Genomic integrity longevity therapeutics $28M–$45M Partial Confidence Implied Valuation from Raise Estimated $7M Full Confidence
53 TruDiagnostic Epigenetic biological-age testing $28M–$42M Partial Confidence Revenue or ARR Multiple Estimate Estimated Undisclosed Low Confidence
54 Edifice Health Inflammatory-healthspan diagnostics $25M–$45M Low Confidence Proxy-Based Estimate Estimated $12M Strong Confidence
55 clock.bio Stem-cell rejuvenation therapeutics $25M–$40M Partial Confidence Implied Valuation from Raise Estimated $9M Strong Confidence
56 AgelessRx Longevity telehealth platform $25M–$38M Strong Confidence Implied Valuation from Raise Implied $8M Partial Confidence
57 Syntara Fibrosis and blood-cancer therapeutics $31M Full Confidence Public Market Cap Observed $151M Partial Confidence
58 AgeX Therapeutics Regenerative therapies for aging diseases $30M Full Confidence Public Market Cap Observed $20M Strong Confidence
59 Maximon Builds and funds longevity companies $20M–$40M Low Confidence Proxy-Based Estimate Estimated Undisclosed Low Confidence
60 Morphoceuticals Bioelectric tissue-regeneration therapies $22M–$38M Low Confidence Implied Valuation from Raise Implied $13M Partial Confidence
61 Reservoir Neuroscience Brain vascular therapeutics $22M–$36M Partial Confidence Implied Valuation from Raise Implied $4M Full Confidence
62 SENISCA RNA senotherapeutics for aging diseases $22M–$35M Partial Confidence Implied Valuation from Raise Estimated $9M Strong Confidence
63 Vasa Therapeutics Cardiovascular aging therapeutics $20M–$34M Partial Confidence Implied Valuation from Raise Estimated $6M Full Confidence
64 Revel Pharmaceuticals Enzyme repair therapeutics $20M–$32M Partial Confidence Comparables-Based Estimate Estimated $8M Strong Confidence
65 NADMED NAD metabolite diagnostics $18M–$30M Partial Confidence Implied Valuation from Raise Estimated $4M Strong Confidence
66 Sierra Sciences Telomere aging research $15M–$30M Low Confidence Revenue or ARR Multiple Estimate Estimated $33M Low Confidence
67 Tally Health Biological age testing platform $15M–$30M Low Confidence Acquisition Value Estimated $10M Full Confidence
68 Longeveron Regenerative cell therapies $22M Full Confidence Public Market Cap Observed $96M Strong Confidence
69 Longevica Longevity therapeutics discovery platform $14M–$28M Low Confidence Acquisition Value Estimated $16M Partial Confidence
70 FoxBio Small-molecule senolytic drug development $12M–$25M Low Confidence Implied Valuation from Raise Estimated $10M Partial Confidence
71 Ichor Therapeutics Aging-focused CRO and therapeutics $12M–$22M Low Confidence Comparables-Based Estimate Estimated $3M Partial Confidence
72 YouthBio Therapeutics Reprogramming therapies for neurodegeneration $10M–$24M Low Confidence Proxy-Based Estimate Estimated Undisclosed Low Confidence
73 Genflow Biosciences SIRT6 gene therapies for aging $15M Full Confidence Public Market Cap Observed $8M Strong Confidence
74 Cleara Biotech Senescence therapies for chronic disease $10M–$18M Partial Confidence Comparables-Based Estimate Estimated $3M Strong Confidence
75 SIWA Therapeutics Senescent-cell antibody therapeutics $8M–$14M Low Confidence Comparables-Based Estimate Estimated $2M Partial Confidence
76 Life Length Telomere diagnostics platform $8M–$14M Partial Confidence Revenue or ARR Multiple Estimate Estimated $3M Partial Confidence
77 ImmuneAge Bio Immune rejuvenation drug discovery $9M–$15M Partial Confidence Active Raise Valuation Estimated $2M Strong Confidence
78 Lysoclear Enzyme therapies for retinal disease $8M–$15M Low Confidence Implied Valuation from Raise Estimated $3M Strong Confidence
79 Auctus Biologics Antibody-mimetic therapeutic scaffolds $6M–$12M Partial Confidence Implied Valuation from Raise Estimated $2M Strong Confidence
80 Five Alarm Bio Small molecules targeting aging $6M–$10M Partial Confidence Comparables-Based Estimate Estimated $1M Partial Confidence
81 NeuroNascent Neural regeneration therapeutics $5M–$11M Low Confidence Proxy-Based Estimate Estimated Undisclosed Low Confidence
82 Longevity Biotech Peptide neurodegeneration therapeutics $5M–$10M Low Confidence Proxy-Based Estimate Estimated Undisclosed Low Confidence
83 Everon Biosciences Anti-aging small-molecule therapeutics $5M–$10M Low Confidence Proxy-Based Estimate Estimated $4M Low Confidence
84 Centagen Epigenetic cellular rejuvenation biologics $4M–$10M Low Confidence Proxy-Based Estimate Estimated Undisclosed Low Confidence
85 BioMarker Pharmaceuticals Aging interventions and wellness products $3M–$6M Low Confidence Revenue or ARR Multiple Estimate Estimated Undisclosed Low Confidence
86 Aelan Cell Technologies Stem-cell medicines and diagnostics $3M–$8M Low Confidence Proxy-Based Estimate Estimated Undisclosed Low Confidence
87 Napa Therapeutics NAD-metabolism small-molecule therapeutics $3M–$8M Low Confidence Proxy-Based Estimate Estimated Undisclosed Low Confidence
88 BioViva Gene therapies for cellular aging $2M–$6M Low Confidence Proxy-Based Estimate Estimated $0M Partial Confidence
89 Genescient Genomics-based aging therapeutics $2M–$5M Low Confidence Proxy-Based Estimate Estimated $1M Low Confidence
90 Chronos Therapeutics Neuropsychiatric preclinical drug assets $1M–$4M Strong Confidence Acquisition Value Observed $16M Strong Confidence
91 Unity Biotechnology Senolytic aging therapies $0M–$5M Low Confidence Proxy-Based Estimate Estimated $297M Partial Confidence
92 Legendary Pharmaceuticals Molecular-damage repair therapeutics $1M–$3M Low Confidence Proxy-Based Estimate Estimated Undisclosed Low Confidence
93 CohBar Mitochondrial peptide therapeutics $0M–$3M Low Confidence Proxy-Based Estimate Estimated $59M Partial Confidence
94 Antoxerene Senolytic small-molecule discovery $0M–$2M Low Confidence Proxy-Based Estimate Estimated $2M Strong Confidence
95 Libella Gene Therapeutics Telomerase gene therapy programs $0M–$2M Low Confidence Proxy-Based Estimate Estimated Undisclosed Low Confidence
96 Gerostate Alpha Drugs targeting aging mechanisms $0M–$1M Low Confidence Proxy-Based Estimate Estimated $3M Partial Confidence
97 Celularity Placenta-derived cell therapies $19M Full Confidence Public Market Cap Observed $408M Partial Confidence

Key valuation trends in the longevity biotech market

Insights

  • The top 10 longevity biotech startups capture approximately 88% of the market’s combined midpoint valuation, showing that investor value is highly concentrated around a small number of major platforms.
  • Altos Labs alone raised $3.0B, more than NewLimit, BioAge Labs, Life Biosciences, Nura Bio, Aeovian Pharmaceuticals, and Juvena Therapeutics combined, highlighting the scale of capital directed toward cellular rejuvenation.
  • Thymmune Therapeutics achieved a $140M acquisition value after raising only $7M, creating a valuation-to-capital ratio of 20 times and one of the strongest capital-efficiency outcomes in the longevity biotech market.
  • MindImmune Therapeutics and Jocasta Neuroscience raised a combined $66M but carry approximately $423M in combined midpoint valuation, reflecting strong demand for aging-related neurodegeneration programs.
  • Generation Lab and GlycanAge raised only $28M in total but hold approximately $120M in combined midpoint value, suggesting that biological-age diagnostics can scale with less capital than clinical drug development.
  • Public longevity biotech companies show sharply different outcomes. BioAge Labs retains a valuation near $1.0B, while several listed regenerative medicine companies trade below $35M despite substantial historical funding.
  • Longeveron’s $22M market capitalization is less than one quarter of its $96M funding total, showing how public markets can heavily compress the value of development-stage regenerative medicine companies.
  • Acquisition outcomes are equally uneven. Alkahest produced a value equal to roughly 3.6 times its funding, while Chronos Therapeutics retained only a small fraction of the capital invested in the company.

A few word about our methodology

As you can see, we built a database that ranks startups in the longevity biotech market based on their current valuation.

Estimating longevity biotech startup valuations is not always straightforward. Many private biotechnology companies do not disclose their valuation, and the available evidence can vary widely based on the company’s financing stage, clinical progress, and ownership structure.

To build this ranking, we applied a structured valuation methodology and cross-checked information across multiple reliable sources.

Whenever possible, we relied on direct disclosures. These include announced valuations from completed funding rounds, public filings for listed biotechnology companies, and official acquisition prices.

When a longevity biotech company is publicly listed, we use its current market capitalization as the reference valuation.

If a company was acquired and no independent valuation can reasonably be estimated today, we use the acquisition price as the main reference point.

When a longevity biotech startup recently raised capital but the valuation was not disclosed, we estimate the implied valuation using typical dilution levels for that stage of biotechnology fundraising.

In some cases, we estimate valuations using operating or development metrics. These can include revenue, recurring revenue, commercial traction, clinical stage, pipeline quality, strategic partnerships, or comparable biotechnology transactions.

When direct financial data is not available, we may rely on carefully selected comparable startups and other signals such as hiring growth, investor quality, pharmaceutical partnerships, clinical progress, intellectual property, and product traction.

All estimates follow a strict evidence hierarchy. Recent funding rounds with announced valuations carry the most weight, followed by public market data, acquisition values, strong operating metrics, clinical evidence, and comparable company analysis.

We also carefully evaluate the age of every data point. Recent information carries more weight, while older funding rounds and valuation references are treated cautiously and adjusted conservatively when necessary.

Whenever information is uncertain or incomplete, we clearly distinguish between confirmed facts and reasonable inferences.

Because valuation data is not always fully public, each longevity biotech startup in the ranking is assigned a confidence level based on the reliability, recency, and consistency of the available evidence.

Full confidence means the valuation is supported by strong and recent evidence. Strong confidence means the estimate is well supported but includes minor inference. Partial confidence means the estimate relies more heavily on indirect signals. Low confidence means available information is limited or inconsistent.

When confidence is lower, we take a more conservative approach by widening the valuation range. This reflects the uncertainty and increases the probability that the true valuation falls within the estimated range.

In a world where LLMs hallucinate and unreliable information is everywhere, our goal is simple: provide data you can trust.

If you want the full detail on a specific valuation estimate, feel free to contact us and we will gladly explain.

Finally, know that we update the dataset once per month, so come back here if you need fresh information.

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