What are the most valued startups in the longevity biotech market?

In our updated market reports, you will find everything you need
The longevity biotech market includes companies developing therapies, diagnostics, research platforms, and healthcare services designed to extend healthy human lifespan.
This ranking compares the latest reported or estimated valuations of longevity biotech startups, and we update the list every month.
The dataset shows a highly concentrated market, with a small group of cellular rejuvenation and drug discovery companies accounting for most of the sector's estimated value.
A quick summary table
| Metric | Value |
|---|---|
| Most valuable longevity biotech startup | Altos Labs, $10.0B–$50.0B |
| Second most valuable longevity biotech startup | BioSplice Therapeutics, $8.0B–$12.0B |
| Median longevity biotech valuation | Approximately $45M |
| Share of longevity biotech value captured by the top 10 | Approximately 88.2% |
| Top longevity biotech valuation vs. median | Approximately 667 times, using valuation midpoints |
| Median longevity biotech valuation-to-capital-raised ratio | Approximately 3.5 times |
| Longevity biotech startups valued at $1B+ | 8 |
Top startups in the longevity biotech market ranked by valuation
Here is an updated table that ranks the top startups in the longevity biotech market based on their latest reported or estimated valuations.
| # | Startup Name | What They Do | Current Valuation ($) | Valuation Confidence Level | Valuation Type | Evidence Status | Total Funding ($) | Funding Confidence Level |
|---|---|---|---|---|---|---|---|---|
| 1 | Altos Labs | Cellular rejuvenation therapies | $10.0B–$50.0B | Low Confidence | Proxy-Based Estimate | Estimated | $3.0B | Full Confidence |
| 2 | BioSplice Therapeutics | Alternative splicing therapeutics | $8.0B–$12.0B | Partial Confidence | Comparables-Based Estimate | Estimated | $778M | Strong Confidence |
| 3 | Calico | Aging biology and therapeutics research | $2.5B–$4.0B | Partial Confidence | Comparables-Based Estimate | Estimated | Undisclosed | Low Confidence |
| 4 | NewLimit | Epigenetic cell reprogramming | $3.1B | Full Confidence | Announced Private Round Valuation | Observed | $715M | Strong Confidence |
| 5 | Insilico Medicine | AI drug discovery | $2.6B | Full Confidence | Public Market Cap | Observed | $811M | Partial Confidence |
| 6 | Retro Biosciences | Healthspan extension therapeutics | $1.8B | Strong Confidence | Announced Private Round Valuation | Observed | $180M | Partial Confidence |
| 7 | BioAge Labs | Metabolic aging therapeutics | $1.0B | Full Confidence | Public Market Cap | Observed | $492M | Strong Confidence |
| 8 | Loyal | Dog longevity medicines | $800M–$1.2B | Strong Confidence | Implied Valuation from Raise | Implied | $250M | Partial Confidence |
| 9 | Cambrian Bio | Healthspan biotech portfolio | $600M–$900M | Partial Confidence | Implied Valuation from Raise | Estimated | $160M | Full Confidence |
| 10 | Life Biosciences | Cellular rejuvenation therapies | $500M–$900M | Strong Confidence | Implied Valuation from Raise | Implied | $237M | Strong Confidence |
| 11 | Nura Bio | Neuroprotective SARM1 inhibitor drugs | $500M–$800M | Strong Confidence | Implied Valuation from Raise | Implied | $215M | Full Confidence |
| 12 | Aeovian Pharmaceuticals | Selective mTORC1 inhibitor drugs | $400M–$650M | Strong Confidence | Implied Valuation from Raise | Implied | $142M | Full Confidence |
| 13 | Alzheon | Alzheimer’s oral therapeutics | $300M–$600M | Partial Confidence | Comparables-Based Estimate | Estimated | $160M | Partial Confidence |
| 14 | Rejuveron Life Sciences | Healthy-aging therapeutics portfolio | $300M–$500M | Partial Confidence | Implied Valuation from Raise | Estimated | $76M | Partial Confidence |
| 15 | Human Longevity | Genomics health intelligence | $250M–$310M | Partial Confidence | Proxy-Based Estimate | Estimated | $330M | Partial Confidence |
| 16 | Juvena Therapeutics | AI-designed regenerative biologics | $225M–$350M | Strong Confidence | Implied Valuation from Raise | Implied | $84M | Strong Confidence |
| 17 | Navitor Pharmaceuticals | mTORC1-targeted neurological therapeutics | $150M–$350M | Partial Confidence | Acquisition Value | Observed | $72M | Strong Confidence |
| 18 | Rubedo Life Sciences | Senescent-cell targeted therapeutics | $180M–$300M | Partial Confidence | Implied Valuation from Raise | Estimated | $52M | Full Confidence |
| 19 | Jocasta Neuroscience | Klotho therapies for cognitive decline | $175M–$290M | Strong Confidence | Implied Valuation from Raise | Implied | $35M | Full Confidence |
| 20 | MindImmune Therapeutics | Neuroinflammation Alzheimer’s therapeutics | $150M–$230M | Strong Confidence | Implied Valuation from Raise | Implied | $31M | Strong Confidence |
| 21 | Amplifier Therapeutics | AMPK metabolic disease therapeutics | $140M–$230M | Partial Confidence | Implied Valuation from Raise | Estimated | $38M | Partial Confidence |
| 22 | Turn Biotechnologies | mRNA cellular rejuvenation therapies | $140M–$220M | Partial Confidence | Comparables-Based Estimate | Estimated | $30M | Partial Confidence |
| 23 | Gordian Biotechnology | In-vivo aging drug discovery | $150M–$210M | Partial Confidence | Comparables-Based Estimate | Estimated | $60M | Partial Confidence |
| 24 | resTORbio | Aging-related mTOR therapeutics | $170M | Full Confidence | Acquisition Value | Observed | $163M | Full Confidence |
| 25 | Elevian | Regenerative GDF11-based medicines | $120M–$200M | Low Confidence | Comparables-Based Estimate | Estimated | $61M | Full Confidence |
| 26 | Gero | AI aging drug discovery | $120M–$180M | Strong Confidence | Implied Valuation from Raise | Implied | $34M | Partial Confidence |
| 27 | Proteostasis Therapeutics | Protein-homeostasis therapeutics | $150M | Strong Confidence | Acquisition Value | Observed | $235M | Strong Confidence |
| 28 | Alkahest | Plasma-proteome aging therapeutics | $146M | Strong Confidence | Acquisition Value | Observed | $41M | Strong Confidence |
| 29 | Thymmune Therapeutics | Regenerative thymic cell therapies | $140M | Full Confidence | Acquisition Value | Observed | $7M | Full Confidence |
| 30 | Mitotech | Mitochondria-targeted small molecules | $90M–$180M | Low Confidence | Comparables-Based Estimate | Estimated | $43M | Low Confidence |
| 31 | Arda Therapeutics | Pathogenic-cell depletion therapies | $70M–$110M | Strong Confidence | Announced Private Round Valuation | Estimated | $43M | Full Confidence |
| 32 | Samsara Therapeutics | Autophagy drugs for neurodegeneration | $75M–$125M | Partial Confidence | Comparables-Based Estimate | Estimated | $28M | Partial Confidence |
| 33 | Tolerance Bio | Thymus immune-tolerance therapies | $80M–$120M | Strong Confidence | Implied Valuation from Raise | Implied | $35M | Strong Confidence |
| 34 | LyGenesis | Lymph-node organ regeneration | $75M–$115M | Partial Confidence | Comparables-Based Estimate | Estimated | $22M | Strong Confidence |
| 35 | Spring Discovery | AI-enabled biological research platform | $60M–$120M | Partial Confidence | Acquisition Value | Estimated | $48M | Partial Confidence |
| 36 | Oisin Biotechnologies | Genetic senolytic aging therapies | $65M–$105M | Partial Confidence | Implied Valuation from Raise | Estimated | $15M | Low Confidence |
| 37 | Repair Biotechnologies | Cholesterol-degrading genetic therapies | $70M–$85M | Strong Confidence | Implied Valuation from Raise | Implied | $26M | Partial Confidence |
| 38 | Rejuvenate Biomed | Sarcopenia drug development | $55M–$95M | Partial Confidence | Comparables-Based Estimate | Estimated | $22M | Strong Confidence |
| 39 | Booster Therapeutics | Proteasome-activating medicines | $60M–$90M | Partial Confidence | Implied Valuation from Raise | Implied | $15M | Full Confidence |
| 40 | Circulate Health | Therapeutic plasma-exchange longevity care | $55M–$80M | Strong Confidence | Implied Valuation from Raise | Implied | $12M | Full Confidence |
| 41 | Shift Bioscience | AI cellular rejuvenation discovery | $65M–$110M | Partial Confidence | Implied Valuation from Raise | Estimated | $29M | Partial Confidence |
| 42 | Generation Lab | Biological-aging diagnostic platform | $50M–$75M | Strong Confidence | Implied Valuation from Raise | Implied | $15M | Strong Confidence |
| 43 | Rejuvenate Bio | Gene therapies for age-related diseases | $59M | Strong Confidence | Active Raise Valuation | Observed | $16M | Strong Confidence |
| 44 | GlycanAge | Glycan biological-age testing | $45M–$70M | Strong Confidence | Implied Valuation from Raise | Implied | $13M | Strong Confidence |
| 45 | Junevity | siRNA cellular-reprogramming therapies | $45M–$65M | Strong Confidence | Implied Valuation from Raise | Implied | $20M | Full Confidence |
| 46 | Epiterna | Aging-focused drug discovery | $40M–$60M | Partial Confidence | Implied Valuation from Raise | Estimated | $11M | Strong Confidence |
| 47 | MitoRx Therapeutics | Mitochondrial metabolic-disease therapeutics | $36M–$55M | Strong Confidence | Implied Valuation from Raise | Implied | $12M | Strong Confidence |
| 48 | Rejuvenation Technologies | Telomere-extending mRNA therapeutics | $35M–$55M | Partial Confidence | Implied Valuation from Raise | Estimated | $11M | Partial Confidence |
| 49 | Deciduous Therapeutics | Senescent-cell immune therapies | $35M–$55M | Low Confidence | Comparables-Based Estimate | Estimated | $17M | Partial Confidence |
| 50 | NaNotics | Subtractive nanoparticle therapeutics | $30M–$50M | Low Confidence | Comparables-Based Estimate | Estimated | $10M | Partial Confidence |
| 51 | Cyclarity Therapeutics | Toxic-cholesterol disease therapeutics | $32M–$42M | Strong Confidence | Announced Private Round Valuation | Estimated | $24M | Strong Confidence |
| 52 | Matter Bio | Genomic integrity longevity therapeutics | $28M–$45M | Partial Confidence | Implied Valuation from Raise | Estimated | $7M | Full Confidence |
| 53 | TruDiagnostic | Epigenetic biological-age testing | $28M–$42M | Partial Confidence | Revenue or ARR Multiple Estimate | Estimated | Undisclosed | Low Confidence |
| 54 | Edifice Health | Inflammatory-healthspan diagnostics | $25M–$45M | Low Confidence | Proxy-Based Estimate | Estimated | $12M | Strong Confidence |
| 55 | clock.bio | Stem-cell rejuvenation therapeutics | $25M–$40M | Partial Confidence | Implied Valuation from Raise | Estimated | $9M | Strong Confidence |
| 56 | AgelessRx | Longevity telehealth platform | $25M–$38M | Strong Confidence | Implied Valuation from Raise | Implied | $8M | Partial Confidence |
| 57 | Syntara | Fibrosis and blood-cancer therapeutics | $31M | Full Confidence | Public Market Cap | Observed | $151M | Partial Confidence |
| 58 | AgeX Therapeutics | Regenerative therapies for aging diseases | $30M | Full Confidence | Public Market Cap | Observed | $20M | Strong Confidence |
| 59 | Maximon | Builds and funds longevity companies | $20M–$40M | Low Confidence | Proxy-Based Estimate | Estimated | Undisclosed | Low Confidence |
| 60 | Morphoceuticals | Bioelectric tissue-regeneration therapies | $22M–$38M | Low Confidence | Implied Valuation from Raise | Implied | $13M | Partial Confidence |
| 61 | Reservoir Neuroscience | Brain vascular therapeutics | $22M–$36M | Partial Confidence | Implied Valuation from Raise | Implied | $4M | Full Confidence |
| 62 | SENISCA | RNA senotherapeutics for aging diseases | $22M–$35M | Partial Confidence | Implied Valuation from Raise | Estimated | $9M | Strong Confidence |
| 63 | Vasa Therapeutics | Cardiovascular aging therapeutics | $20M–$34M | Partial Confidence | Implied Valuation from Raise | Estimated | $6M | Full Confidence |
| 64 | Revel Pharmaceuticals | Enzyme repair therapeutics | $20M–$32M | Partial Confidence | Comparables-Based Estimate | Estimated | $8M | Strong Confidence |
| 65 | NADMED | NAD metabolite diagnostics | $18M–$30M | Partial Confidence | Implied Valuation from Raise | Estimated | $4M | Strong Confidence |
| 66 | Sierra Sciences | Telomere aging research | $15M–$30M | Low Confidence | Revenue or ARR Multiple Estimate | Estimated | $33M | Low Confidence |
| 67 | Tally Health | Biological age testing platform | $15M–$30M | Low Confidence | Acquisition Value | Estimated | $10M | Full Confidence |
| 68 | Longeveron | Regenerative cell therapies | $22M | Full Confidence | Public Market Cap | Observed | $96M | Strong Confidence |
| 69 | Longevica | Longevity therapeutics discovery platform | $14M–$28M | Low Confidence | Acquisition Value | Estimated | $16M | Partial Confidence |
| 70 | FoxBio | Small-molecule senolytic drug development | $12M–$25M | Low Confidence | Implied Valuation from Raise | Estimated | $10M | Partial Confidence |
| 71 | Ichor Therapeutics | Aging-focused CRO and therapeutics | $12M–$22M | Low Confidence | Comparables-Based Estimate | Estimated | $3M | Partial Confidence |
| 72 | YouthBio Therapeutics | Reprogramming therapies for neurodegeneration | $10M–$24M | Low Confidence | Proxy-Based Estimate | Estimated | Undisclosed | Low Confidence |
| 73 | Genflow Biosciences | SIRT6 gene therapies for aging | $15M | Full Confidence | Public Market Cap | Observed | $8M | Strong Confidence |
| 74 | Cleara Biotech | Senescence therapies for chronic disease | $10M–$18M | Partial Confidence | Comparables-Based Estimate | Estimated | $3M | Strong Confidence |
| 75 | SIWA Therapeutics | Senescent-cell antibody therapeutics | $8M–$14M | Low Confidence | Comparables-Based Estimate | Estimated | $2M | Partial Confidence |
| 76 | Life Length | Telomere diagnostics platform | $8M–$14M | Partial Confidence | Revenue or ARR Multiple Estimate | Estimated | $3M | Partial Confidence |
| 77 | ImmuneAge Bio | Immune rejuvenation drug discovery | $9M–$15M | Partial Confidence | Active Raise Valuation | Estimated | $2M | Strong Confidence |
| 78 | Lysoclear | Enzyme therapies for retinal disease | $8M–$15M | Low Confidence | Implied Valuation from Raise | Estimated | $3M | Strong Confidence |
| 79 | Auctus Biologics | Antibody-mimetic therapeutic scaffolds | $6M–$12M | Partial Confidence | Implied Valuation from Raise | Estimated | $2M | Strong Confidence |
| 80 | Five Alarm Bio | Small molecules targeting aging | $6M–$10M | Partial Confidence | Comparables-Based Estimate | Estimated | $1M | Partial Confidence |
| 81 | NeuroNascent | Neural regeneration therapeutics | $5M–$11M | Low Confidence | Proxy-Based Estimate | Estimated | Undisclosed | Low Confidence |
| 82 | Longevity Biotech | Peptide neurodegeneration therapeutics | $5M–$10M | Low Confidence | Proxy-Based Estimate | Estimated | Undisclosed | Low Confidence |
| 83 | Everon Biosciences | Anti-aging small-molecule therapeutics | $5M–$10M | Low Confidence | Proxy-Based Estimate | Estimated | $4M | Low Confidence |
| 84 | Centagen | Epigenetic cellular rejuvenation biologics | $4M–$10M | Low Confidence | Proxy-Based Estimate | Estimated | Undisclosed | Low Confidence |
| 85 | BioMarker Pharmaceuticals | Aging interventions and wellness products | $3M–$6M | Low Confidence | Revenue or ARR Multiple Estimate | Estimated | Undisclosed | Low Confidence |
| 86 | Aelan Cell Technologies | Stem-cell medicines and diagnostics | $3M–$8M | Low Confidence | Proxy-Based Estimate | Estimated | Undisclosed | Low Confidence |
| 87 | Napa Therapeutics | NAD-metabolism small-molecule therapeutics | $3M–$8M | Low Confidence | Proxy-Based Estimate | Estimated | Undisclosed | Low Confidence |
| 88 | BioViva | Gene therapies for cellular aging | $2M–$6M | Low Confidence | Proxy-Based Estimate | Estimated | $0M | Partial Confidence |
| 89 | Genescient | Genomics-based aging therapeutics | $2M–$5M | Low Confidence | Proxy-Based Estimate | Estimated | $1M | Low Confidence |
| 90 | Chronos Therapeutics | Neuropsychiatric preclinical drug assets | $1M–$4M | Strong Confidence | Acquisition Value | Observed | $16M | Strong Confidence |
| 91 | Unity Biotechnology | Senolytic aging therapies | $0M–$5M | Low Confidence | Proxy-Based Estimate | Estimated | $297M | Partial Confidence |
| 92 | Legendary Pharmaceuticals | Molecular-damage repair therapeutics | $1M–$3M | Low Confidence | Proxy-Based Estimate | Estimated | Undisclosed | Low Confidence |
| 93 | CohBar | Mitochondrial peptide therapeutics | $0M–$3M | Low Confidence | Proxy-Based Estimate | Estimated | $59M | Partial Confidence |
| 94 | Antoxerene | Senolytic small-molecule discovery | $0M–$2M | Low Confidence | Proxy-Based Estimate | Estimated | $2M | Strong Confidence |
| 95 | Libella Gene Therapeutics | Telomerase gene therapy programs | $0M–$2M | Low Confidence | Proxy-Based Estimate | Estimated | Undisclosed | Low Confidence |
| 96 | Gerostate Alpha | Drugs targeting aging mechanisms | $0M–$1M | Low Confidence | Proxy-Based Estimate | Estimated | $3M | Partial Confidence |
| 97 | Celularity | Placenta-derived cell therapies | $19M | Full Confidence | Public Market Cap | Observed | $408M | Partial Confidence |
Key valuation trends in the longevity biotech market
Insights
- The top 10 longevity biotech startups capture approximately 88% of the market’s combined midpoint valuation, showing that investor value is highly concentrated around a small number of major platforms.
- Altos Labs alone raised $3.0B, more than NewLimit, BioAge Labs, Life Biosciences, Nura Bio, Aeovian Pharmaceuticals, and Juvena Therapeutics combined, highlighting the scale of capital directed toward cellular rejuvenation.
- Thymmune Therapeutics achieved a $140M acquisition value after raising only $7M, creating a valuation-to-capital ratio of 20 times and one of the strongest capital-efficiency outcomes in the longevity biotech market.
- MindImmune Therapeutics and Jocasta Neuroscience raised a combined $66M but carry approximately $423M in combined midpoint valuation, reflecting strong demand for aging-related neurodegeneration programs.
- Generation Lab and GlycanAge raised only $28M in total but hold approximately $120M in combined midpoint value, suggesting that biological-age diagnostics can scale with less capital than clinical drug development.
- Public longevity biotech companies show sharply different outcomes. BioAge Labs retains a valuation near $1.0B, while several listed regenerative medicine companies trade below $35M despite substantial historical funding.
- Longeveron’s $22M market capitalization is less than one quarter of its $96M funding total, showing how public markets can heavily compress the value of development-stage regenerative medicine companies.
- Acquisition outcomes are equally uneven. Alkahest produced a value equal to roughly 3.6 times its funding, while Chronos Therapeutics retained only a small fraction of the capital invested in the company.
A few word about our methodology
As you can see, we built a database that ranks startups in the longevity biotech market based on their current valuation.
Estimating longevity biotech startup valuations is not always straightforward. Many private biotechnology companies do not disclose their valuation, and the available evidence can vary widely based on the company’s financing stage, clinical progress, and ownership structure.
To build this ranking, we applied a structured valuation methodology and cross-checked information across multiple reliable sources.
Whenever possible, we relied on direct disclosures. These include announced valuations from completed funding rounds, public filings for listed biotechnology companies, and official acquisition prices.
When a longevity biotech company is publicly listed, we use its current market capitalization as the reference valuation.
If a company was acquired and no independent valuation can reasonably be estimated today, we use the acquisition price as the main reference point.
When a longevity biotech startup recently raised capital but the valuation was not disclosed, we estimate the implied valuation using typical dilution levels for that stage of biotechnology fundraising.
In some cases, we estimate valuations using operating or development metrics. These can include revenue, recurring revenue, commercial traction, clinical stage, pipeline quality, strategic partnerships, or comparable biotechnology transactions.
When direct financial data is not available, we may rely on carefully selected comparable startups and other signals such as hiring growth, investor quality, pharmaceutical partnerships, clinical progress, intellectual property, and product traction.
All estimates follow a strict evidence hierarchy. Recent funding rounds with announced valuations carry the most weight, followed by public market data, acquisition values, strong operating metrics, clinical evidence, and comparable company analysis.
We also carefully evaluate the age of every data point. Recent information carries more weight, while older funding rounds and valuation references are treated cautiously and adjusted conservatively when necessary.
Whenever information is uncertain or incomplete, we clearly distinguish between confirmed facts and reasonable inferences.
Because valuation data is not always fully public, each longevity biotech startup in the ranking is assigned a confidence level based on the reliability, recency, and consistency of the available evidence.
Full confidence means the valuation is supported by strong and recent evidence. Strong confidence means the estimate is well supported but includes minor inference. Partial confidence means the estimate relies more heavily on indirect signals. Low confidence means available information is limited or inconsistent.
When confidence is lower, we take a more conservative approach by widening the valuation range. This reflects the uncertainty and increases the probability that the true valuation falls within the estimated range.
In a world where LLMs hallucinate and unreliable information is everywhere, our goal is simple: provide data you can trust.
If you want the full detail on a specific valuation estimate, feel free to contact us and we will gladly explain.
Finally, know that we update the dataset once per month, so come back here if you need fresh information.
Related blog posts
- What are the latest fundraising trends in the longevity biotech market?
- Which companies have raised the most funding in the longevity biotech market?
- Is fundraising strong in the longevity biotech market right now?
- A full list of funding deals in the longevity biotech market
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