What are the most valued startups in the biopharma market?

Last updated: 13 July 2026

market research pitch 2026

In our updated market reports, you will find everything you need

The biopharma market includes companies developing medicines, vaccines, cell therapies, gene therapies, drug discovery platforms and manufacturing infrastructure.

This ranking compares 100 biopharma companies using their latest reported market capitalizations, acquisition values and estimated private valuations.

We update this biopharma startup list every month to reflect public market movements, funding rounds, acquisitions and new valuation evidence.

A quick summary table

Metric Value
Most valuable biopharma company Alnylam Pharmaceuticals, $44.7B
Second most valuable biopharma company BeOne Medicines, $31.3B
Median biopharma valuation $1.8B
Share of biopharma valuation captured by the top 10 53.1%
Top biopharma valuation versus median 24.8 times
Median biopharma valuation-to-capital-raised ratio 2.8 times
Biopharma companies valued at $1B+ 67

Top startups in the biopharma market ranked by valuation

Here is an updated table that ranks the top startups in the biopharma market based on their latest reported or estimated valuations.

# Startup Name What They Do Current Valuation ($) Valuation Confidence Level Valuation Type Evidence Status Total Funding ($) Funding Confidence Level
1 Alnylam Pharmaceuticals RNAi therapeutics $44.7B Full Confidence Public Market Cap Observed $81M Partial Confidence
2 BeOne Medicines Global oncology medicines $31.3B Full Confidence Public Market Cap Observed $5.2B Partial Confidence
3 Moderna mRNA medicines and vaccines $29.2B Full Confidence Public Market Cap Observed $2.3B Strong Confidence
4 Roivant Sciences Biopharma company creation platform $25.1B Full Confidence Public Market Cap Observed $1.9B Strong Confidence
5 BioNTech mRNA immunotherapies and vaccines $22.2B Full Confidence Public Market Cap Observed $925M Full Confidence
6 Isomorphic Labs AI drug design $14.0B–$26.0B Partial Confidence Implied Valuation from Raise Implied $600M Partial Confidence
7 Innovent Biologics Antibodies and oncology biologics $19.3B Full Confidence Public Market Cap Observed $3.5B Strong Confidence
8 Madrigal Pharmaceuticals MASH liver disease therapies $16.3B Full Confidence Public Market Cap Observed $73M Partial Confidence
9 BridgeBio Pharma Genetic disease medicines $15.3B Full Confidence Public Market Cap Observed $1.8B Strong Confidence
10 Akeso Bispecific antibodies and immunotherapies $11.3B Full Confidence Public Market Cap Observed $825M Partial Confidence
11 Legend Biotech CAR-T cancer therapies $10.0B Full Confidence Public Market Cap Observed $1.1B Partial Confidence
12 Apogee Therapeutics Long-acting inflammatory disease biologics $10.0B Full Confidence Public Market Cap Observed $859M Strong Confidence
13 RemeGen ADCs and autoimmune biologics $8.8B Full Confidence Public Market Cap Observed $1.0B Strong Confidence
14 Crinetics Pharmaceuticals Rare endocrine disease therapeutics $8.7B Full Confidence Public Market Cap Observed $1.2B Strong Confidence
15 Vaxcyte Bacterial disease vaccines $8.3B Full Confidence Public Market Cap Observed $4.8B Strong Confidence
16 Arcellx Controllable CAR-T cancer therapies $7.8B Full Confidence Acquisition Value Observed $651M Strong Confidence
17 Scholar Rock Growth-factor biology medicines $7.4B Full Confidence Public Market Cap Observed $403M Partial Confidence
18 Harbour BioMed Antibody therapeutics platform $5.7B Full Confidence Public Market Cap Observed $534M Strong Confidence
19 Apellis Pharmaceuticals Complement-targeted rare disease medicines $5.6B Full Confidence Acquisition Value Observed $1.6B Partial Confidence
20 CRISPR Therapeutics CRISPR gene-editing medicines $5.4B Full Confidence Public Market Cap Observed $1.6B Strong Confidence
21 Denali Therapeutics Neurodegenerative disease therapeutics $5.1B Full Confidence Public Market Cap Observed $597M Full Confidence
22 Viking Therapeutics Metabolic and endocrine therapies $4.8B Full Confidence Public Market Cap Observed $927M Strong Confidence
23 Junshi Biosciences Antibody therapeutics across diseases $4.7B Full Confidence Public Market Cap Observed $1.2B Strong Confidence
24 Altos Labs Cellular rejuvenation therapies $3.0B–$5.5B Low Confidence Comparables-Based Estimate Estimated $3.0B Strong Confidence
25 XtalPi AI-powered drug discovery platform $4.2B Full Confidence Public Market Cap Observed $1.3B Partial Confidence
26 Parabilis Medicines Intracellular cancer-targeting peptides $3.9B Full Confidence Public Market Cap Observed $1.7B Strong Confidence
27 ElevateBio Cell and gene platform $2.7B–$5.0B Partial Confidence Implied Valuation from Raise Implied $1.2B Full Confidence
28 Relay Therapeutics Protein-motion drug discovery $3.7B Full Confidence Public Market Cap Observed $1.4B Strong Confidence
29 Beam Therapeutics Base-editing genetic medicines $3.7B Full Confidence Public Market Cap Observed $1.5B Strong Confidence
30 Alumis Precision medicines for autoimmune diseases $3.7B Full Confidence Public Market Cap Observed $779M Full Confidence
31 Arcutis Biotherapeutics Topical inflammatory skin medicines $3.7B Full Confidence Public Market Cap Observed $1.1B Strong Confidence
32 Arcus Biosciences Combination cancer immunotherapies $3.2B Full Confidence Public Market Cap Observed $1.4B Strong Confidence
33 Cellares Automated cell therapy manufacturing $2.2B–$4.1B Partial Confidence Implied Valuation from Raise Implied $682M Full Confidence
34 Kailera Therapeutics Obesity and metabolic disease medicines $3.1B Full Confidence Public Market Cap Observed $1.7B Full Confidence
35 Dizal Pharmaceutical Precision medicines for cancer $3.0B Full Confidence Public Market Cap Observed $431M Strong Confidence
36 Insilico Medicine Generative AI drug discovery $2.8B Full Confidence Public Market Cap Observed $643M Strong Confidence
37 Tarsus Pharmaceuticals Eye disease therapeutics $2.8B Full Confidence Public Market Cap Observed $269M Strong Confidence
38 Xaira Therapeutics AI drug discovery $2.0B–$3.5B Partial Confidence Comparables-Based Estimate Estimated $1.0B Strong Confidence
39 Kriya Therapeutics Gene therapies for chronic diseases $2.1B–$3.2B Strong Confidence Implied Valuation from Raise Implied $938M Partial Confidence
40 Orna Therapeutics Circular RNA cell therapies $2.4B Strong Confidence Acquisition Value Observed $301M Strong Confidence
41 Mirador Therapeutics Precision immunology and fibrosis medicines $1.7B–$3.1B Partial Confidence Implied Valuation from Raise Implied $650M Full Confidence
42 National Resilience Biopharma manufacturing infrastructure $1.5B–$3.0B Low Confidence Proxy-Based Estimate Estimated $2.0B Partial Confidence
43 Zai Lab Asia-focused innovative medicines $2.2B Full Confidence Public Market Cap Observed $2.1B Strong Confidence
44 Insitro Machine-learning drug discovery platform $1.8B–$2.4B Partial Confidence Comparables-Based Estimate Estimated $643M Full Confidence
45 Capstan Therapeutics In-vivo CAR-T cell engineering $2.1B Full Confidence Acquisition Value Observed $340M Full Confidence
46 Recursion Pharmaceuticals AI-enabled drug discovery $2.0B Full Confidence Public Market Cap Observed $922M Partial Confidence
47 Rapport Therapeutics Precision neuromedicine therapies $2.0B Full Confidence Public Market Cap Observed $424M Full Confidence
48 Ascentage Pharma Apoptosis-targeted cancer therapies $1.9B Full Confidence Public Market Cap Observed $492M Partial Confidence
49 Tessera Therapeutics Gene writing medicines $1.2B–$2.5B Low Confidence Implied Valuation from Raise Implied $580M Partial Confidence
50 Absci AI-designed biologic medicines $1.8B Full Confidence Public Market Cap Observed $723M Partial Confidence
51 Intellia Therapeutics In-vivo CRISPR medicines $1.8B Full Confidence Public Market Cap Observed $1.4B Strong Confidence
52 Iovance Biotherapeutics Tumor-infiltrating lymphocyte therapies $1.8B Full Confidence Public Market Cap Observed $461M Low Confidence
53 Maze Therapeutics Genetically informed precision medicines $1.8B Full Confidence Public Market Cap Observed $936M Strong Confidence
54 ArsenalBio Programmable solid-tumor cell therapies $1.5B–$2.0B Strong Confidence Announced Private Round Valuation Estimated $630M Full Confidence
55 Nimbus Therapeutics Computational small-molecule medicines $1.4B–$2.0B Partial Confidence Implied Valuation from Raise Implied $637M Partial Confidence
56 GenFleet Therapeutics Oncology and immunology medicines $1.7B Full Confidence Public Market Cap Observed $399M Partial Confidence
57 Septerna Oral GPCR-targeted medicines $1.6B Full Confidence Public Market Cap Observed $581M Full Confidence
58 Genesis Therapeutics AI small-molecule discovery $1.2B–$1.8B Partial Confidence Implied Valuation from Raise Implied $280M Strong Confidence
59 Owkin AI precision medicine platform $1.2B–$1.7B Partial Confidence Comparables-Based Estimate Estimated $304M Strong Confidence
60 Valo Health AI-powered drug development $1.0B–$1.5B Partial Confidence Comparables-Based Estimate Estimated $400M Partial Confidence
61 Latigo Biotherapeutics Non-opioid pain medicines $1.0B–$1.5B Partial Confidence Implied Valuation from Raise Implied $285M Full Confidence
62 Schrödinger Drug software and therapeutics $1.2B Full Confidence Public Market Cap Observed $342M Strong Confidence
63 Everest Medicines Asia-focused licensed medicines $1.2B Full Confidence Public Market Cap Observed $811M Partial Confidence
64 Verve Therapeutics Cardiovascular gene-editing medicines $1.0B–$1.3B Strong Confidence Acquisition Value Observed $689M Full Confidence
65 Sana Biotechnology Engineered cell medicines $1.1B Full Confidence Public Market Cap Observed $1.5B Partial Confidence
66 CStone Pharmaceuticals Oncology and immunotherapy medicines $1.1B Full Confidence Public Market Cap Observed $895M Full Confidence
67 Generate:Biomedicines AI protein therapeutics $1.0B Full Confidence Public Market Cap Observed $1.1B Strong Confidence
68 Mammoth Biosciences CRISPR therapeutics and diagnostics $800M–$1.1B Partial Confidence Comparables-Based Estimate Estimated $263M Strong Confidence
69 Umoja Biopharma In-vivo CAR-T therapies $700M–$1.0B Partial Confidence Implied Valuation from Raise Implied $363M Full Confidence
70 Prime Medicine Prime-editing genetic therapies $749M Full Confidence Public Market Cap Observed $795M Strong Confidence
71 Affini-T Therapeutics TCR therapies for solid tumors $550M–$850M Low Confidence Comparables-Based Estimate Estimated $193M Partial Confidence
72 Verge Genomics AI neurological drug discovery $500M–$850M Low Confidence Comparables-Based Estimate Estimated $134M Full Confidence
73 Kyverna Therapeutics Autoimmune CAR-T therapies $593M Full Confidence Public Market Cap Observed $489M Full Confidence
74 Sage Therapeutics CNS disorder medicines $561M Strong Confidence Acquisition Value Observed $235M Partial Confidence
75 Ring Therapeutics Anellovirus-based genetic medicines $400M–$700M Low Confidence Implied Valuation from Raise Implied $230M Partial Confidence
76 I-Mab Antibody cancer immunology drugs $530M Full Confidence Public Market Cap Observed $907M Partial Confidence
77 Allogene Therapeutics Off-the-shelf CAR-T therapies $505M Full Confidence Public Market Cap Observed $1.7B Strong Confidence
78 Laronde Endless RNA medicines $350M–$600M Low Confidence Acquisition Value Estimated $440M Full Confidence
79 Asher Biotherapeutics Selective immune-cell therapies $370M–$550M Partial Confidence Implied Valuation from Raise Implied $218M Full Confidence
80 Autolus Therapeutics Engineered T-cell cancer therapies $450M Full Confidence Public Market Cap Observed $642M Strong Confidence
81 Century Therapeutics iPSC-derived cell therapies $447M Full Confidence Public Market Cap Observed $681M Full Confidence
82 ReCode Therapeutics Targeted LNP genetic medicines $300M–$500M Partial Confidence Comparables-Based Estimate Estimated $359M Strong Confidence
83 Fate Therapeutics iPSC-derived immune-cell therapies $373M Full Confidence Public Market Cap Observed $844M Partial Confidence
84 Eikon Therapeutics Live-cell drug discovery $361M Full Confidence Public Market Cap Observed $1.5B Full Confidence
85 Atomwise AI small-molecule screening $250M–$450M Low Confidence Implied Valuation from Raise Implied $218M Partial Confidence
86 Lyell Immunopharma T-cell reprogramming therapies $333M Full Confidence Public Market Cap Observed $1.0B Strong Confidence
87 Editas Medicine CRISPR gene-editing therapies $323M Full Confidence Public Market Cap Observed $968M Strong Confidence
88 Neumora Therapeutics Precision medicines for brain diseases $303M Full Confidence Public Market Cap Observed $862M Full Confidence
89 2seventy bio Multiple-myeloma cell therapy $286M Full Confidence Acquisition Value Observed $170M Strong Confidence
90 Cartesian Therapeutics mRNA autoimmune cell therapies $260M Full Confidence Public Market Cap Observed $190M Partial Confidence
91 Nkarta Natural-killer cell therapies $238M Full Confidence Public Market Cap Observed $618M Strong Confidence
92 Artiva Biotherapeutics Allogeneic NK-cell therapies $232M Full Confidence Public Market Cap Observed $665M Full Confidence
93 CARGO Therapeutics CAR-T therapies for lymphoma $190M Strong Confidence Acquisition Value Observed $591M Strong Confidence
94 Caribou Biosciences Genome-edited allogeneic cell therapies $186M Full Confidence Public Market Cap Observed $520M Partial Confidence
95 Connect Biopharma T-cell inflammatory disease medicines $155M Full Confidence Public Market Cap Observed $386M Full Confidence
96 CANbridge Pharmaceuticals Rare disease medicines $152M Full Confidence Public Market Cap Observed $218M Partial Confidence
97 Brii Biosciences Infectious disease medicines $96M Full Confidence Public Market Cap Observed $733M Strong Confidence
98 BenevolentAI AI-enabled drug discovery $50M–$80M Partial Confidence Acquisition Value Estimated $434M Partial Confidence
99 Metagenomi Gene-editing therapeutic platform $47M Full Confidence Public Market Cap Observed $444M Strong Confidence
100 Senti Biosciences Gene-circuit cell therapies $31M Full Confidence Public Market Cap Observed $346M Strong Confidence

Key valuation trends in the biopharma market

Insights

  • The top 10 biopharma companies represent about 53% of the dataset’s total valuation, showing that sector value remains concentrated among a relatively small group of commercial and late-stage businesses.
  • Alnylam Pharmaceuticals is valued at almost 25 times the median biopharma company, which highlights the valuation gap between proven commercial platforms and the wider development-stage market.
  • Moderna, Roivant Sciences and BioNTech have a combined valuation of approximately $76.5B, equal to more than 17% of the total value represented in this biopharma ranking.
  • BioNTech’s $22.2B valuation is about 24 times its reported funding, showing how successful product commercialization can create substantially more value than cumulative external financing.
  • Apogee Therapeutics and Arcellx both achieved valuation-to-funding ratios near 12 times, placing the companies among the strongest apparent capital-efficiency outcomes in the biopharma dataset.
  • RemeGen, Harbour BioMed and Junshi Biosciences hold approximately $19.2B in combined value against about $2.7B of funding, showing the growing strength of Asian antibody developers.
  • CRISPR Therapeutics, Beam Therapeutics, Intellia Therapeutics and Verve Therapeutics represent about $12.1B in combined value, but the four gene-editing companies have raised approximately $5.2B.
  • Arcellx, Orna Therapeutics, Capstan Therapeutics and 2seventy bio generated approximately $12.6B of combined acquisition value, confirming continued strategic demand for differentiated cell and RNA platforms.
  • Allogene Therapeutics, Lyell Immunopharma, Nkarta and Artiva Biotherapeutics are collectively valued below their combined historical funding, reflecting the public market pressure on capital-intensive cell therapy companies.
  • Eikon Therapeutics has raised approximately $1.5B but carries a $361M valuation, creating a valuation deficit above $1.1B and illustrating the scale of public market compression.
  • Metagenomi and Senti Biosciences raised approximately $790M combined but have a combined market value of only $78M, showing how clinical risk can rapidly outweigh substantial financing histories.
  • Tarsus Pharmaceuticals reached a $2.8B valuation after raising $269M, an approximately tenfold ratio that demonstrates the value of focused execution in specialty biopharma markets.

A few word about our methodology

As you can see, we built a database that ranks startups and public companies in the biopharma market based on their current valuation.

Estimating biopharma valuations is not always straightforward. Many private companies do not disclose their valuation, while public biopharma valuations can change every trading day.

To build this ranking, we applied a structured valuation methodology and cross-checked information across multiple reliable sources.

Whenever possible, we relied on direct disclosures. These include announced valuations from completed funding rounds, public filings for listed biopharma companies and official acquisition prices.

When a biopharma company is publicly listed, we use its current market capitalization as the reference valuation.

If a biopharma company was acquired and no independent valuation can reasonably be estimated today, we use the acquisition price as the main reference point.

When a biopharma startup recently raised capital but did not disclose its valuation, we estimate the implied valuation using typical dilution levels for that fundraising stage.

In some cases, we estimate valuations using operating and development metrics. These can include revenue, licensing income, clinical-stage progress, commercial traction and valuation multiples from comparable biopharma companies.

When direct financial data is unavailable, we may use carefully selected comparable companies and other signals. These signals can include pipeline maturity, clinical results, strategic partnerships, investor quality, hiring growth and platform traction.

Clinical development risk is an important part of biopharma valuation. A successful trial, regulatory decision or commercial launch can increase value quickly, while a failed program can remove substantial value.

All estimates follow a strict evidence hierarchy. Recent funding rounds with announced valuations carry the most weight, followed by public market values, acquisition prices, operating metrics and comparable company analysis.

We also evaluate the age of every data point. Recent information carries more weight, while older funding rounds and historical valuations are treated cautiously.

Whenever information is uncertain or incomplete, we clearly distinguish between confirmed facts, implied valuations and reasonable estimates.

Because biopharma valuation data is not always fully public, each company in the ranking is assigned a confidence level based on the reliability, recency and consistency of the available evidence.

Full confidence means the valuation is supported by strong and recent evidence. Strong confidence means the estimate is well supported but includes minor inference. Partial confidence means the estimate relies more heavily on indirect signals. Low confidence means available information is limited or inconsistent.

When confidence is lower, we take a more conservative approach by widening the valuation range. This reflects the uncertainty and increases the probability that the true valuation falls within the estimated range.

Funding figures also require careful interpretation. Reported totals can include equity financing, public offerings, private placements, debt, grants, collaboration payments or other forms of capital.

In a world where LLMs hallucinate and unreliable information is everywhere, our goal is simple: provide data you can trust.

If you want the full detail on a specific valuation estimate, feel free to contact us and we will gladly explain.

Finally, know that we update the dataset once per month, so come back here if you need fresh information.

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