What are the most valued startups in the biotechnology market?

Last updated: 13 July 2026

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The biotechnology market includes drug developers, genomics platforms, diagnostics companies, research software providers, and advanced manufacturing businesses.

This ranking compares 97 biotechnology startups and former startups using their latest reported or estimated valuations.

We update this list every month to reflect public market movements, acquisitions, funding rounds, and newly available valuation evidence.

And if you want to better understand this new industry, you can download our pitch covering the biotechnology market.

A quick summary table

Metric Value
Most valuable biotechnology startup Isomorphic Labs, $14.0B–$26.0B
Second most valuable biotechnology startup CG Oncology, $6.1B
Median biotechnology valuation Approximately $1.0B
Biotechnology valuation captured by the top 10 Approximately 38.3%
Top biotechnology valuation versus median Approximately 20 times
Median biotechnology valuation-to-capital-raised ratio Approximately 2.1 times
Biotechnology startups valued at $1B+ 49
Market map chart showing top companies and startups in the biotechnology market

This market map, featured in our biotechnology market deck, highlights top companies and startups in the biotechnology market

Top startups in the biotechnology market ranked by valuation

Here is an updated table that ranks the top startups in the biotechnology market based on their latest reported or estimated valuations.

If you want more detaild about their fundraising activity, you can check our list of the startups who have raised the most funding in the biotechnology market.

# Startup Name What They Do Current Valuation ($) Valuation Confidence Level Valuation Type Evidence Status Total Funding ($) Funding Confidence Level
1 Isomorphic Labs AI-powered drug design $14.0B–$26.0B Partial Confidence Implied Valuation from Raise Implied $2.7B Full Confidence
2 CG Oncology Bladder cancer immunotherapy $6.1B Full Confidence Public Market Cap Observed $936M Full Confidence
3 Stemcentrx Cancer stem-cell targeted therapies $5.8B Full Confidence Acquisition Value Observed $500M Partial Confidence
4 Harbour BioMed Antibody oncology therapeutics $5.4B Full Confidence Public Market Cap Observed $543M Strong Confidence
5 Caris Life Sciences AI precision oncology profiling $5.0B Full Confidence Public Market Cap Observed $1.9B Strong Confidence
6 Samsung Bioepis Develops and commercializes biosimilars $4.4B–$4.8B Strong Confidence Acquisition Value Implied $700M Low Confidence
7 Benchling Life-sciences R&D cloud software $3.8B–$4.8B Partial Confidence Revenue or ARR Multiple Estimate Estimated $412M Strong Confidence
8 Haihe Biopharma Innovative oncology drug development $3.8B–$4.5B Partial Confidence IPO or Listing Range Valuation Estimated $374M Partial Confidence
9 RayzeBio Targeted radiopharmaceutical cancer treatments $4.1B Full Confidence Acquisition Value Observed $708M Full Confidence
10 Alumis Precision immunology therapies $3.8B Full Confidence Public Market Cap Observed $529M Full Confidence
11 FogPharma / Parabilis Medicines Intracellular peptide cancer medicines $3.7B Full Confidence Public Market Cap Observed $1.6B Full Confidence
12 Altos Labs Cellular rejuvenation therapeutics research $2.5B–$4.0B Partial Confidence Proxy-Based Estimate Estimated $3.0B Strong Confidence
13 MGI Tech Genomic sequencing and multiomics platforms $3.1B Full Confidence Public Market Cap Observed $1.7B Strong Confidence
14 Kailera Therapeutics Obesity and metabolic therapeutics $3.1B Full Confidence Public Market Cap Observed $1.7B Full Confidence
15 Cellares Automated cell-therapy manufacturing $2.6B–$3.5B Strong Confidence Implied Valuation from Raise Implied $682M Full Confidence
16 Kriya Therapeutics Gene therapies for chronic diseases $2.4B–$3.6B Partial Confidence Implied Valuation from Raise Implied $921M Strong Confidence
17 Insilico Medicine Generative-AI drug discovery $2.9B Full Confidence Public Market Cap Observed $510M Strong Confidence
18 Abogen Biosciences mRNA vaccines and therapeutics $2.0B–$3.7B Low Confidence Comparables-Based Estimate Estimated $1.1B Strong Confidence
19 Carmot Therapeutics Metabolic disease drug development $2.7B Full Confidence Acquisition Value Observed $386M Partial Confidence
20 GRAIL Multi-cancer blood testing $2.6B Full Confidence Public Market Cap Observed $2.4B Strong Confidence
21 TauRx Pharmaceuticals Tau-targeting Alzheimer’s therapies $2.0B–$3.0B Partial Confidence Comparables-Based Estimate Estimated $434M Partial Confidence
22 Voronoi Kinase inhibitor drug discovery $2.5B Full Confidence Public Market Cap Observed $92M Low Confidence
23 ElevateBio Cell and gene therapy platform $2.0B–$3.0B Partial Confidence Implied Valuation from Raise Estimated $1.2B Full Confidence
24 Mirador Therapeutics Precision immunology medicines $1.7B–$2.5B Strong Confidence Implied Valuation from Raise Implied $650M Strong Confidence
25 Capstan Therapeutics In-vivo cell engineering $2.1B Full Confidence Acquisition Value Observed $340M Full Confidence
26 Orna Therapeutics Circular RNA in-vivo therapies $1.5B–$2.4B Strong Confidence Acquisition Value Observed $301M Strong Confidence
27 Insitro Machine-learning drug discovery $1.8B–$2.4B Partial Confidence Comparables-Based Estimate Estimated $643M Full Confidence
28 Tessera Therapeutics Gene-writing genetic medicines $1.5B–$2.5B Partial Confidence Comparables-Based Estimate Estimated $610M Strong Confidence
29 Vividion Therapeutics Undruggable-target therapeutics $2.0B Full Confidence Acquisition Value Observed $267M Full Confidence
30 Apollo Therapeutics Portfolio biopharma drug development $1.4B–$2.2B Partial Confidence Implied Valuation from Raise Implied $422M Strong Confidence
31 Bicara Therapeutics Dual-action cancer biologics $1.9B Full Confidence Public Market Cap Observed $628M Full Confidence
32 Maze Therapeutics Genetics-based precision medicines $1.8B Full Confidence Public Market Cap Observed $636M Full Confidence
33 Formation Bio AI-native drug development $1.5B–$1.9B Partial Confidence Revenue or ARR Multiple Estimate Estimated $608M Partial Confidence
34 MapLight Therapeutics CNS disorder drug development $1.7B Full Confidence Public Market Cap Observed $959M Strong Confidence
35 Everest Medicines Asia-focused commercial biopharma $1.6B Full Confidence Public Market Cap Observed $811M Strong Confidence
36 ADARx Pharmaceuticals RNA-targeting therapeutics $1.2B–$2.0B Partial Confidence Implied Valuation from Raise Implied $353M Partial Confidence
37 ArsenalBio Programmable cell therapies $1.1B–$1.9B Partial Confidence Implied Valuation from Raise Implied $630M Full Confidence
38 Shanghai Henlius Biotech Develops biologics and biosimilars $1.6B–$1.8B Strong Confidence Public Market Cap Estimated $757M Partial Confidence
39 Owkin AI-powered biology and drug discovery $1.4B–$1.8B Partial Confidence Comparables-Based Estimate Estimated $304M Partial Confidence
40 Element Biosciences DNA sequencing platforms $1.2B–$1.8B Strong Confidence Implied Valuation from Raise Implied $678M Full Confidence
41 Zenas BioPharma Immunology therapies $1.4B Full Confidence Public Market Cap Observed $543M Strong Confidence
42 Areteia Therapeutics Oral eosinophilic asthma therapy $1.0B–$1.6B Partial Confidence Implied Valuation from Raise Implied $425M Full Confidence
43 Upstream Bio Inflammatory disease antibodies $1.3B Full Confidence Public Market Cap Observed $693M Full Confidence
44 Xaira Therapeutics AI drug discovery platform $1.0B–$1.5B Partial Confidence Proxy-Based Estimate Estimated $1.0B Full Confidence
45 Treeline Biosciences Precision oncology medicines $1.0B–$1.4B Partial Confidence Implied Valuation from Raise Implied $1.1B Partial Confidence
46 AltruBio Immune disease therapeutics $900M–$1.5B Partial Confidence Implied Valuation from Raise Implied $340M Partial Confidence
47 Thousand Oaks Biopharmaceuticals Biologics manufacturing and culture media $900M–$1.5B Low Confidence Comparables-Based Estimate Estimated $346M Strong Confidence
48 Avistone Pharmaceuticals Precision oncology therapeutics $900M–$1.4B Partial Confidence Implied Valuation from Raise Implied $340M Strong Confidence
49 Amolyt Pharma Rare endocrine peptide therapeutics $1.1B Full Confidence Acquisition Value Observed $293M Full Confidence
50 Freenome Multiomics cancer blood tests $900M–$1.1B Partial Confidence IPO or Listing Range Valuation Estimated $1.3B Full Confidence
51 Generate Biomedicines AI-designed protein therapeutics $1.0B Full Confidence Public Market Cap Observed $1.1B Full Confidence
52 Neurona Therapeutics Regenerative neural cell therapies $650M–$1.2B Strong Confidence Acquisition Value Observed $418M Partial Confidence
53 Rakuten Medical Light-activated cancer immunotherapy $700M–$1.1B Strong Confidence Implied Valuation from Raise Implied $757M Partial Confidence
54 Odyssey Therapeutics Autoimmune precision medicines $900M Full Confidence Public Market Cap Observed $979M Strong Confidence
55 AvenCell Switchable CAR-T therapies $700M–$1.1B Partial Confidence Implied Valuation from Raise Implied $362M Full Confidence
56 Shanghai Cell Therapy Group Cell therapies and storage services $750M–$900M Strong Confidence IPO or Listing Range Valuation Estimated $211M Partial Confidence
57 Karius Infectious-disease blood diagnostics $650M–$950M Partial Confidence Implied Valuation from Raise Implied $320M Strong Confidence
58 Valo Health AI drug discovery platform $500M–$800M Partial Confidence Comparables-Based Estimate Estimated $400M Partial Confidence
59 Avenzo Therapeutics Oncology drug candidates $500M–$800M Partial Confidence Implied Valuation from Raise Implied $446M Partial Confidence
60 TORL BioTherapeutics Antibody cancer therapies $650M–$950M Partial Confidence Implied Valuation from Raise Implied $450M Partial Confidence
61 ReNAgade Therapeutics RNA delivery and editing platform $600M–$1.0B Low Confidence Proxy-Based Estimate Estimated $300M Full Confidence
62 SOTIO Biotech Clinical-stage cancer immunotherapies $600M–$900M Partial Confidence Comparables-Based Estimate Estimated $316M Strong Confidence
63 Helix Population genomics infrastructure $600M–$900M Low Confidence Comparables-Based Estimate Estimated $350M Partial Confidence
64 DELFI Diagnostics Cancer liquid-biopsy testing $650M–$800M Partial Confidence Comparables-Based Estimate Estimated $332M Strong Confidence
65 Frontier Medicines Targets previously undruggable proteins $550M–$800M Partial Confidence Implied Valuation from Raise Implied $256M Full Confidence
66 Ultima Genomics Low-cost genome sequencing $500M–$750M Partial Confidence Proxy-Based Estimate Estimated $600M Strong Confidence
67 DNA Script Enzymatic DNA printing $500M–$700M Partial Confidence Comparables-Based Estimate Estimated $315M Strong Confidence
68 DNAnexus Cloud genomic data platform $500M–$700M Partial Confidence Revenue or ARR Multiple Estimate Estimated $390M Partial Confidence
69 XtalPi AI drug discovery platform $500M–$700M Partial Confidence Public Market Cap Estimated $861M Partial Confidence
70 Chime Biologics Biologics development and manufacturing $450M–$700M Low Confidence Comparables-Based Estimate Estimated $315M Full Confidence
71 Forge Biologics Gene therapy manufacturing services $554M Full Confidence Acquisition Value Observed $330M Strong Confidence
72 Castle Creek Biosciences Rare-disease gene therapies $450M–$650M Partial Confidence Comparables-Based Estimate Estimated $193M Partial Confidence
73 Laronde Endless-RNA programmable medicines $350M–$600M Low Confidence Proxy-Based Estimate Estimated $490M Full Confidence
74 Genor Biopharma Antibody oncology medicines $466M Full Confidence Public Market Cap Observed $588M Strong Confidence
75 Obsidian Therapeutics Engineered cell therapies $400M–$450M Strong Confidence IPO or Listing Range Valuation Implied $325M Full Confidence
76 Eikon Therapeutics Protein-dynamics drug discovery $378M Full Confidence Public Market Cap Observed $1.5B Full Confidence
77 Lyell Immunopharma CAR-T therapies for solid tumors $371M Full Confidence Public Market Cap Observed $1.0B Partial Confidence
78 Normax Biomed mRNA vaccines and manufacturing $250M–$450M Low Confidence Proxy-Based Estimate Estimated $303M Low Confidence
79 Synthego CRISPR research and manufacturing tools $250M–$450M Low Confidence Acquisition Value Estimated $460M Strong Confidence
80 eGenesis Gene-edited transplant organs $280M–$380M Partial Confidence Comparables-Based Estimate Estimated $454M Strong Confidence
81 Neumora Therapeutics Precision brain disease medicines $303M Full Confidence Public Market Cap Observed $862M Full Confidence
82 ReCode Therapeutics Targeted genetic-medicine delivery $220M–$380M Partial Confidence Implied Valuation from Raise Implied $371M Strong Confidence
83 Human Longevity Genomics-based preventive healthcare $200M–$300M Partial Confidence Comparables-Based Estimate Estimated $370M Partial Confidence
84 ACELYRIN Immunology drug development $250M Strong Confidence Acquisition Value Observed $550M Strong Confidence
85 Invivyd Antibody protection against viruses $248M Full Confidence Public Market Cap Observed $863M Strong Confidence
86 Genuity Science Population genomic data analytics $150M–$300M Low Confidence Acquisition Value Estimated $455M Partial Confidence
87 Botamedi Algae-derived therapeutic compounds $180M–$300M Low Confidence Proxy-Based Estimate Estimated $159M Low Confidence
88 Beijing Biostar Technologies Synthetic-biology oncology medicines $172M Full Confidence Public Market Cap Observed $180M Partial Confidence
89 Intarcia Therapeutics Implantable drug-delivery systems $150M Partial Confidence Acquisition Value Observed $1.8B Partial Confidence
90 Senda Biosciences Programmable mRNA delivery medicines $80M–$160M Low Confidence Proxy-Based Estimate Estimated $266M Strong Confidence
91 Brii Biosciences Infectious-disease therapies $105M Full Confidence Public Market Cap Observed $734M Strong Confidence
92 3D Medicines Cancer immunotherapy drug development $72M Full Confidence Public Market Cap Observed $140M Partial Confidence
93 Metagenomi Next-generation gene-editing medicines $48M Full Confidence Public Market Cap Observed $460M Partial Confidence
94 GenapSys Semiconductor DNA sequencing systems $42M Strong Confidence Acquisition Value Observed $206M Partial Confidence
95 LianBio Asia-focused drug development partnerships $0M–$20M Low Confidence Proxy-Based Estimate Estimated $638M Strong Confidence
96 Mojave Pharma Neuropsychiatric drug development $0M–$10M Low Confidence Proxy-Based Estimate Estimated $220M Low Confidence
97 CardioDx Cardiovascular genomic diagnostics $0M–$5M Low Confidence Proxy-Based Estimate Estimated $282M Partial Confidence
Chart comparing the 2026 size of the biotechnology market with other markets of similar size

This chart, featured in our biotechnology market deck, compares the 2026 size of the biotechnology market with other markets of similar size

Key valuation trends in the biotechnology market

Insights

  • Isomorphic Labs has a midpoint valuation near $20.0B, more than three times CG Oncology’s $6.1B market capitalization, which shows the premium attached to leading AI drug-design platforms.
  • The ten largest biotechnology companies account for approximately 38% of the combined valuation in this ranking, so substantial biotechnology value remains distributed across the wider market.
  • RayzeBio, Capstan Therapeutics, Vividion Therapeutics, and Thrive Earlier Detection each produced acquisition values of roughly six times or more their reported funding, highlighting the strategic value of differentiated therapeutic and diagnostic platforms.
  • Public biotechnology outcomes remain sharply divided. CG Oncology is worth $6.1B, while Brii Biosciences is worth about $105M despite raising $734M.
  • Clinical setbacks can erase years of biotechnology investment. Neumora Therapeutics is worth about 35% of its reported funding, while Eikon Therapeutics trades at roughly one-quarter of the capital it raised.
  • Alumis has one of the strongest public-market capital-efficiency profiles in the ranking, with a $3.8B valuation equal to approximately 7.2 times its $529M funding.
  • Manufacturing platforms can attract large valuations, but realized multiples are often lower. Forge Biologics sold for about 1.7 times funding, well below the acquisition multiples achieved by Vividion and Capstan.
Chart showing Vertex’s strategy in the biotechnology market

This chart, featured in our biotechnology market deck, looks at Vertex’s strategy in biotechnology

A few word about our methodology

As you can see, we built a database that ranks startups in the biotechnology market based on their current valuation.

Estimating biotechnology startup valuations is not always straightforward. Many biotechnology companies do not publicly disclose their valuation, and the available information can vary widely depending on the company, clinical stage, and financing history.

To build this ranking, we applied a structured valuation methodology and cross-checked information across multiple reliable sources.

Whenever possible, we relied on direct disclosures. These include announced valuations from completed funding rounds, public filings for listed biotechnology companies, or official acquisition prices.

When a biotechnology company is publicly listed, we use its current market capitalization as the reference valuation.

If a biotechnology startup was acquired and no independent valuation can reasonably be estimated today, we use the acquisition price as the main reference point.

When a biotechnology startup recently raised capital but the valuation was not disclosed, we estimate the implied valuation using typical dilution levels for that stage of fundraising.

In some cases, we also estimate valuations using operating metrics such as revenue, ARR, licensing income, commercial traction, or clinical progress, combined with valuation multiples from comparable biotechnology companies.

When direct financial data is not available, we may rely on carefully selected comparable biotechnology startups and other signals such as pipeline quality, clinical results, investor quality, partnership activity, hiring growth, or product traction.

All estimates follow a strict evidence hierarchy. Recent biotechnology funding rounds with announced valuations carry the most weight, followed by public market values, acquisition prices, strong operating metrics, and comparable company analysis.

We also carefully evaluate the age of every data point. Recent information carries more weight, while older biotechnology valuation data is treated cautiously and adjusted conservatively when necessary.

Whenever information is uncertain or incomplete, we clearly distinguish between confirmed facts and reasonable inferences.

Because biotechnology valuation data is not always fully public, each startup in the ranking is assigned a confidence level based on the reliability, recency, and consistency of the available evidence.

Full confidence means the valuation is supported by strong and recent evidence. Strong confidence means the estimate is well supported but includes minor inference. Partial confidence means the estimate relies more heavily on indirect signals. Low confidence means available information is limited or inconsistent.

When confidence is lower, we take a more conservative approach by widening the valuation range. This helps reflect the uncertainty and increases the probability that the true biotechnology startup valuation falls within the estimated range.

This reflects how we conduct all our research, including the work behind our report covering the biotechnology market.

In a world where LLMs hallucinate and unreliable information is everywhere, our goal is simple: provide data you can trust.

If you want the full detail on a specific valuation estimate, feel free to contact us and we will gladly explain.

Finally, know that we update the dataset once per month, so come back here if you need fresh information.

Chart showing the projected CAGR of the biotechnology market

This chart, featured in our biotechnology market deck, illustrates yearly funding for biotechnology startups

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