What are the most valued startups in the biotechnology market?
Download our beautiful pitch about the biotechnology market

In our biotechnology market deck, you will find everything you need to understand the market
The biotechnology market includes drug developers, genomics platforms, diagnostics companies, research software providers, and advanced manufacturing businesses.
This ranking compares 97 biotechnology startups and former startups using their latest reported or estimated valuations.
We update this list every month to reflect public market movements, acquisitions, funding rounds, and newly available valuation evidence.
And if you want to better understand this new industry, you can download our pitch covering the biotechnology market.
A quick summary table
| Metric | Value |
|---|---|
| Most valuable biotechnology startup | Isomorphic Labs, $14.0B–$26.0B |
| Second most valuable biotechnology startup | CG Oncology, $6.1B |
| Median biotechnology valuation | Approximately $1.0B |
| Biotechnology valuation captured by the top 10 | Approximately 38.3% |
| Top biotechnology valuation versus median | Approximately 20 times |
| Median biotechnology valuation-to-capital-raised ratio | Approximately 2.1 times |
| Biotechnology startups valued at $1B+ | 49 |

This market map, featured in our biotechnology market deck, highlights top companies and startups in the biotechnology market
Top startups in the biotechnology market ranked by valuation
Here is an updated table that ranks the top startups in the biotechnology market based on their latest reported or estimated valuations.
If you want more detaild about their fundraising activity, you can check our list of the startups who have raised the most funding in the biotechnology market.
| # | Startup Name | What They Do | Current Valuation ($) | Valuation Confidence Level | Valuation Type | Evidence Status | Total Funding ($) | Funding Confidence Level |
|---|---|---|---|---|---|---|---|---|
| 1 | Isomorphic Labs | AI-powered drug design | $14.0B–$26.0B | Partial Confidence | Implied Valuation from Raise | Implied | $2.7B | Full Confidence |
| 2 | CG Oncology | Bladder cancer immunotherapy | $6.1B | Full Confidence | Public Market Cap | Observed | $936M | Full Confidence |
| 3 | Stemcentrx | Cancer stem-cell targeted therapies | $5.8B | Full Confidence | Acquisition Value | Observed | $500M | Partial Confidence |
| 4 | Harbour BioMed | Antibody oncology therapeutics | $5.4B | Full Confidence | Public Market Cap | Observed | $543M | Strong Confidence |
| 5 | Caris Life Sciences | AI precision oncology profiling | $5.0B | Full Confidence | Public Market Cap | Observed | $1.9B | Strong Confidence |
| 6 | Samsung Bioepis | Develops and commercializes biosimilars | $4.4B–$4.8B | Strong Confidence | Acquisition Value | Implied | $700M | Low Confidence |
| 7 | Benchling | Life-sciences R&D cloud software | $3.8B–$4.8B | Partial Confidence | Revenue or ARR Multiple Estimate | Estimated | $412M | Strong Confidence |
| 8 | Haihe Biopharma | Innovative oncology drug development | $3.8B–$4.5B | Partial Confidence | IPO or Listing Range Valuation | Estimated | $374M | Partial Confidence |
| 9 | RayzeBio | Targeted radiopharmaceutical cancer treatments | $4.1B | Full Confidence | Acquisition Value | Observed | $708M | Full Confidence |
| 10 | Alumis | Precision immunology therapies | $3.8B | Full Confidence | Public Market Cap | Observed | $529M | Full Confidence |
| 11 | FogPharma / Parabilis Medicines | Intracellular peptide cancer medicines | $3.7B | Full Confidence | Public Market Cap | Observed | $1.6B | Full Confidence |
| 12 | Altos Labs | Cellular rejuvenation therapeutics research | $2.5B–$4.0B | Partial Confidence | Proxy-Based Estimate | Estimated | $3.0B | Strong Confidence |
| 13 | MGI Tech | Genomic sequencing and multiomics platforms | $3.1B | Full Confidence | Public Market Cap | Observed | $1.7B | Strong Confidence |
| 14 | Kailera Therapeutics | Obesity and metabolic therapeutics | $3.1B | Full Confidence | Public Market Cap | Observed | $1.7B | Full Confidence |
| 15 | Cellares | Automated cell-therapy manufacturing | $2.6B–$3.5B | Strong Confidence | Implied Valuation from Raise | Implied | $682M | Full Confidence |
| 16 | Kriya Therapeutics | Gene therapies for chronic diseases | $2.4B–$3.6B | Partial Confidence | Implied Valuation from Raise | Implied | $921M | Strong Confidence |
| 17 | Insilico Medicine | Generative-AI drug discovery | $2.9B | Full Confidence | Public Market Cap | Observed | $510M | Strong Confidence |
| 18 | Abogen Biosciences | mRNA vaccines and therapeutics | $2.0B–$3.7B | Low Confidence | Comparables-Based Estimate | Estimated | $1.1B | Strong Confidence |
| 19 | Carmot Therapeutics | Metabolic disease drug development | $2.7B | Full Confidence | Acquisition Value | Observed | $386M | Partial Confidence |
| 20 | GRAIL | Multi-cancer blood testing | $2.6B | Full Confidence | Public Market Cap | Observed | $2.4B | Strong Confidence |
| 21 | TauRx Pharmaceuticals | Tau-targeting Alzheimer’s therapies | $2.0B–$3.0B | Partial Confidence | Comparables-Based Estimate | Estimated | $434M | Partial Confidence |
| 22 | Voronoi | Kinase inhibitor drug discovery | $2.5B | Full Confidence | Public Market Cap | Observed | $92M | Low Confidence |
| 23 | ElevateBio | Cell and gene therapy platform | $2.0B–$3.0B | Partial Confidence | Implied Valuation from Raise | Estimated | $1.2B | Full Confidence |
| 24 | Mirador Therapeutics | Precision immunology medicines | $1.7B–$2.5B | Strong Confidence | Implied Valuation from Raise | Implied | $650M | Strong Confidence |
| 25 | Capstan Therapeutics | In-vivo cell engineering | $2.1B | Full Confidence | Acquisition Value | Observed | $340M | Full Confidence |
| 26 | Orna Therapeutics | Circular RNA in-vivo therapies | $1.5B–$2.4B | Strong Confidence | Acquisition Value | Observed | $301M | Strong Confidence |
| 27 | Insitro | Machine-learning drug discovery | $1.8B–$2.4B | Partial Confidence | Comparables-Based Estimate | Estimated | $643M | Full Confidence |
| 28 | Tessera Therapeutics | Gene-writing genetic medicines | $1.5B–$2.5B | Partial Confidence | Comparables-Based Estimate | Estimated | $610M | Strong Confidence |
| 29 | Vividion Therapeutics | Undruggable-target therapeutics | $2.0B | Full Confidence | Acquisition Value | Observed | $267M | Full Confidence |
| 30 | Apollo Therapeutics | Portfolio biopharma drug development | $1.4B–$2.2B | Partial Confidence | Implied Valuation from Raise | Implied | $422M | Strong Confidence |
| 31 | Bicara Therapeutics | Dual-action cancer biologics | $1.9B | Full Confidence | Public Market Cap | Observed | $628M | Full Confidence |
| 32 | Maze Therapeutics | Genetics-based precision medicines | $1.8B | Full Confidence | Public Market Cap | Observed | $636M | Full Confidence |
| 33 | Formation Bio | AI-native drug development | $1.5B–$1.9B | Partial Confidence | Revenue or ARR Multiple Estimate | Estimated | $608M | Partial Confidence |
| 34 | MapLight Therapeutics | CNS disorder drug development | $1.7B | Full Confidence | Public Market Cap | Observed | $959M | Strong Confidence |
| 35 | Everest Medicines | Asia-focused commercial biopharma | $1.6B | Full Confidence | Public Market Cap | Observed | $811M | Strong Confidence |
| 36 | ADARx Pharmaceuticals | RNA-targeting therapeutics | $1.2B–$2.0B | Partial Confidence | Implied Valuation from Raise | Implied | $353M | Partial Confidence |
| 37 | ArsenalBio | Programmable cell therapies | $1.1B–$1.9B | Partial Confidence | Implied Valuation from Raise | Implied | $630M | Full Confidence |
| 38 | Shanghai Henlius Biotech | Develops biologics and biosimilars | $1.6B–$1.8B | Strong Confidence | Public Market Cap | Estimated | $757M | Partial Confidence |
| 39 | Owkin | AI-powered biology and drug discovery | $1.4B–$1.8B | Partial Confidence | Comparables-Based Estimate | Estimated | $304M | Partial Confidence |
| 40 | Element Biosciences | DNA sequencing platforms | $1.2B–$1.8B | Strong Confidence | Implied Valuation from Raise | Implied | $678M | Full Confidence |
| 41 | Zenas BioPharma | Immunology therapies | $1.4B | Full Confidence | Public Market Cap | Observed | $543M | Strong Confidence |
| 42 | Areteia Therapeutics | Oral eosinophilic asthma therapy | $1.0B–$1.6B | Partial Confidence | Implied Valuation from Raise | Implied | $425M | Full Confidence |
| 43 | Upstream Bio | Inflammatory disease antibodies | $1.3B | Full Confidence | Public Market Cap | Observed | $693M | Full Confidence |
| 44 | Xaira Therapeutics | AI drug discovery platform | $1.0B–$1.5B | Partial Confidence | Proxy-Based Estimate | Estimated | $1.0B | Full Confidence |
| 45 | Treeline Biosciences | Precision oncology medicines | $1.0B–$1.4B | Partial Confidence | Implied Valuation from Raise | Implied | $1.1B | Partial Confidence |
| 46 | AltruBio | Immune disease therapeutics | $900M–$1.5B | Partial Confidence | Implied Valuation from Raise | Implied | $340M | Partial Confidence |
| 47 | Thousand Oaks Biopharmaceuticals | Biologics manufacturing and culture media | $900M–$1.5B | Low Confidence | Comparables-Based Estimate | Estimated | $346M | Strong Confidence |
| 48 | Avistone Pharmaceuticals | Precision oncology therapeutics | $900M–$1.4B | Partial Confidence | Implied Valuation from Raise | Implied | $340M | Strong Confidence |
| 49 | Amolyt Pharma | Rare endocrine peptide therapeutics | $1.1B | Full Confidence | Acquisition Value | Observed | $293M | Full Confidence |
| 50 | Freenome | Multiomics cancer blood tests | $900M–$1.1B | Partial Confidence | IPO or Listing Range Valuation | Estimated | $1.3B | Full Confidence |
| 51 | Generate Biomedicines | AI-designed protein therapeutics | $1.0B | Full Confidence | Public Market Cap | Observed | $1.1B | Full Confidence |
| 52 | Neurona Therapeutics | Regenerative neural cell therapies | $650M–$1.2B | Strong Confidence | Acquisition Value | Observed | $418M | Partial Confidence |
| 53 | Rakuten Medical | Light-activated cancer immunotherapy | $700M–$1.1B | Strong Confidence | Implied Valuation from Raise | Implied | $757M | Partial Confidence |
| 54 | Odyssey Therapeutics | Autoimmune precision medicines | $900M | Full Confidence | Public Market Cap | Observed | $979M | Strong Confidence |
| 55 | AvenCell | Switchable CAR-T therapies | $700M–$1.1B | Partial Confidence | Implied Valuation from Raise | Implied | $362M | Full Confidence |
| 56 | Shanghai Cell Therapy Group | Cell therapies and storage services | $750M–$900M | Strong Confidence | IPO or Listing Range Valuation | Estimated | $211M | Partial Confidence |
| 57 | Karius | Infectious-disease blood diagnostics | $650M–$950M | Partial Confidence | Implied Valuation from Raise | Implied | $320M | Strong Confidence |
| 58 | Valo Health | AI drug discovery platform | $500M–$800M | Partial Confidence | Comparables-Based Estimate | Estimated | $400M | Partial Confidence |
| 59 | Avenzo Therapeutics | Oncology drug candidates | $500M–$800M | Partial Confidence | Implied Valuation from Raise | Implied | $446M | Partial Confidence |
| 60 | TORL BioTherapeutics | Antibody cancer therapies | $650M–$950M | Partial Confidence | Implied Valuation from Raise | Implied | $450M | Partial Confidence |
| 61 | ReNAgade Therapeutics | RNA delivery and editing platform | $600M–$1.0B | Low Confidence | Proxy-Based Estimate | Estimated | $300M | Full Confidence |
| 62 | SOTIO Biotech | Clinical-stage cancer immunotherapies | $600M–$900M | Partial Confidence | Comparables-Based Estimate | Estimated | $316M | Strong Confidence |
| 63 | Helix | Population genomics infrastructure | $600M–$900M | Low Confidence | Comparables-Based Estimate | Estimated | $350M | Partial Confidence |
| 64 | DELFI Diagnostics | Cancer liquid-biopsy testing | $650M–$800M | Partial Confidence | Comparables-Based Estimate | Estimated | $332M | Strong Confidence |
| 65 | Frontier Medicines | Targets previously undruggable proteins | $550M–$800M | Partial Confidence | Implied Valuation from Raise | Implied | $256M | Full Confidence |
| 66 | Ultima Genomics | Low-cost genome sequencing | $500M–$750M | Partial Confidence | Proxy-Based Estimate | Estimated | $600M | Strong Confidence |
| 67 | DNA Script | Enzymatic DNA printing | $500M–$700M | Partial Confidence | Comparables-Based Estimate | Estimated | $315M | Strong Confidence |
| 68 | DNAnexus | Cloud genomic data platform | $500M–$700M | Partial Confidence | Revenue or ARR Multiple Estimate | Estimated | $390M | Partial Confidence |
| 69 | XtalPi | AI drug discovery platform | $500M–$700M | Partial Confidence | Public Market Cap | Estimated | $861M | Partial Confidence |
| 70 | Chime Biologics | Biologics development and manufacturing | $450M–$700M | Low Confidence | Comparables-Based Estimate | Estimated | $315M | Full Confidence |
| 71 | Forge Biologics | Gene therapy manufacturing services | $554M | Full Confidence | Acquisition Value | Observed | $330M | Strong Confidence |
| 72 | Castle Creek Biosciences | Rare-disease gene therapies | $450M–$650M | Partial Confidence | Comparables-Based Estimate | Estimated | $193M | Partial Confidence |
| 73 | Laronde | Endless-RNA programmable medicines | $350M–$600M | Low Confidence | Proxy-Based Estimate | Estimated | $490M | Full Confidence |
| 74 | Genor Biopharma | Antibody oncology medicines | $466M | Full Confidence | Public Market Cap | Observed | $588M | Strong Confidence |
| 75 | Obsidian Therapeutics | Engineered cell therapies | $400M–$450M | Strong Confidence | IPO or Listing Range Valuation | Implied | $325M | Full Confidence |
| 76 | Eikon Therapeutics | Protein-dynamics drug discovery | $378M | Full Confidence | Public Market Cap | Observed | $1.5B | Full Confidence |
| 77 | Lyell Immunopharma | CAR-T therapies for solid tumors | $371M | Full Confidence | Public Market Cap | Observed | $1.0B | Partial Confidence |
| 78 | Normax Biomed | mRNA vaccines and manufacturing | $250M–$450M | Low Confidence | Proxy-Based Estimate | Estimated | $303M | Low Confidence |
| 79 | Synthego | CRISPR research and manufacturing tools | $250M–$450M | Low Confidence | Acquisition Value | Estimated | $460M | Strong Confidence |
| 80 | eGenesis | Gene-edited transplant organs | $280M–$380M | Partial Confidence | Comparables-Based Estimate | Estimated | $454M | Strong Confidence |
| 81 | Neumora Therapeutics | Precision brain disease medicines | $303M | Full Confidence | Public Market Cap | Observed | $862M | Full Confidence |
| 82 | ReCode Therapeutics | Targeted genetic-medicine delivery | $220M–$380M | Partial Confidence | Implied Valuation from Raise | Implied | $371M | Strong Confidence |
| 83 | Human Longevity | Genomics-based preventive healthcare | $200M–$300M | Partial Confidence | Comparables-Based Estimate | Estimated | $370M | Partial Confidence |
| 84 | ACELYRIN | Immunology drug development | $250M | Strong Confidence | Acquisition Value | Observed | $550M | Strong Confidence |
| 85 | Invivyd | Antibody protection against viruses | $248M | Full Confidence | Public Market Cap | Observed | $863M | Strong Confidence |
| 86 | Genuity Science | Population genomic data analytics | $150M–$300M | Low Confidence | Acquisition Value | Estimated | $455M | Partial Confidence |
| 87 | Botamedi | Algae-derived therapeutic compounds | $180M–$300M | Low Confidence | Proxy-Based Estimate | Estimated | $159M | Low Confidence |
| 88 | Beijing Biostar Technologies | Synthetic-biology oncology medicines | $172M | Full Confidence | Public Market Cap | Observed | $180M | Partial Confidence |
| 89 | Intarcia Therapeutics | Implantable drug-delivery systems | $150M | Partial Confidence | Acquisition Value | Observed | $1.8B | Partial Confidence |
| 90 | Senda Biosciences | Programmable mRNA delivery medicines | $80M–$160M | Low Confidence | Proxy-Based Estimate | Estimated | $266M | Strong Confidence |
| 91 | Brii Biosciences | Infectious-disease therapies | $105M | Full Confidence | Public Market Cap | Observed | $734M | Strong Confidence |
| 92 | 3D Medicines | Cancer immunotherapy drug development | $72M | Full Confidence | Public Market Cap | Observed | $140M | Partial Confidence |
| 93 | Metagenomi | Next-generation gene-editing medicines | $48M | Full Confidence | Public Market Cap | Observed | $460M | Partial Confidence |
| 94 | GenapSys | Semiconductor DNA sequencing systems | $42M | Strong Confidence | Acquisition Value | Observed | $206M | Partial Confidence |
| 95 | LianBio | Asia-focused drug development partnerships | $0M–$20M | Low Confidence | Proxy-Based Estimate | Estimated | $638M | Strong Confidence |
| 96 | Mojave Pharma | Neuropsychiatric drug development | $0M–$10M | Low Confidence | Proxy-Based Estimate | Estimated | $220M | Low Confidence |
| 97 | CardioDx | Cardiovascular genomic diagnostics | $0M–$5M | Low Confidence | Proxy-Based Estimate | Estimated | $282M | Partial Confidence |

This chart, featured in our biotechnology market deck, compares the 2026 size of the biotechnology market with other markets of similar size
Key valuation trends in the biotechnology market
Insights
- Isomorphic Labs has a midpoint valuation near $20.0B, more than three times CG Oncology’s $6.1B market capitalization, which shows the premium attached to leading AI drug-design platforms.
- The ten largest biotechnology companies account for approximately 38% of the combined valuation in this ranking, so substantial biotechnology value remains distributed across the wider market.
- RayzeBio, Capstan Therapeutics, Vividion Therapeutics, and Thrive Earlier Detection each produced acquisition values of roughly six times or more their reported funding, highlighting the strategic value of differentiated therapeutic and diagnostic platforms.
- Public biotechnology outcomes remain sharply divided. CG Oncology is worth $6.1B, while Brii Biosciences is worth about $105M despite raising $734M.
- Clinical setbacks can erase years of biotechnology investment. Neumora Therapeutics is worth about 35% of its reported funding, while Eikon Therapeutics trades at roughly one-quarter of the capital it raised.
- Alumis has one of the strongest public-market capital-efficiency profiles in the ranking, with a $3.8B valuation equal to approximately 7.2 times its $529M funding.
- Manufacturing platforms can attract large valuations, but realized multiples are often lower. Forge Biologics sold for about 1.7 times funding, well below the acquisition multiples achieved by Vividion and Capstan.

This chart, featured in our biotechnology market deck, looks at Vertex’s strategy in biotechnology
A few word about our methodology
As you can see, we built a database that ranks startups in the biotechnology market based on their current valuation.
Estimating biotechnology startup valuations is not always straightforward. Many biotechnology companies do not publicly disclose their valuation, and the available information can vary widely depending on the company, clinical stage, and financing history.
To build this ranking, we applied a structured valuation methodology and cross-checked information across multiple reliable sources.
Whenever possible, we relied on direct disclosures. These include announced valuations from completed funding rounds, public filings for listed biotechnology companies, or official acquisition prices.
When a biotechnology company is publicly listed, we use its current market capitalization as the reference valuation.
If a biotechnology startup was acquired and no independent valuation can reasonably be estimated today, we use the acquisition price as the main reference point.
When a biotechnology startup recently raised capital but the valuation was not disclosed, we estimate the implied valuation using typical dilution levels for that stage of fundraising.
In some cases, we also estimate valuations using operating metrics such as revenue, ARR, licensing income, commercial traction, or clinical progress, combined with valuation multiples from comparable biotechnology companies.
When direct financial data is not available, we may rely on carefully selected comparable biotechnology startups and other signals such as pipeline quality, clinical results, investor quality, partnership activity, hiring growth, or product traction.
All estimates follow a strict evidence hierarchy. Recent biotechnology funding rounds with announced valuations carry the most weight, followed by public market values, acquisition prices, strong operating metrics, and comparable company analysis.
We also carefully evaluate the age of every data point. Recent information carries more weight, while older biotechnology valuation data is treated cautiously and adjusted conservatively when necessary.
Whenever information is uncertain or incomplete, we clearly distinguish between confirmed facts and reasonable inferences.
Because biotechnology valuation data is not always fully public, each startup in the ranking is assigned a confidence level based on the reliability, recency, and consistency of the available evidence.
Full confidence means the valuation is supported by strong and recent evidence. Strong confidence means the estimate is well supported but includes minor inference. Partial confidence means the estimate relies more heavily on indirect signals. Low confidence means available information is limited or inconsistent.
When confidence is lower, we take a more conservative approach by widening the valuation range. This helps reflect the uncertainty and increases the probability that the true biotechnology startup valuation falls within the estimated range.
This reflects how we conduct all our research, including the work behind our report covering the biotechnology market.
In a world where LLMs hallucinate and unreliable information is everywhere, our goal is simple: provide data you can trust.
If you want the full detail on a specific valuation estimate, feel free to contact us and we will gladly explain.
Finally, know that we update the dataset once per month, so come back here if you need fresh information.

This chart, featured in our biotechnology market deck, illustrates yearly funding for biotechnology startups
Related blog posts
- The latest news in the biotechnology market
- The latest funding news in the biotechnology market
- What has changed recently in the biotechnology market?
- How funding activity has changed in the biotechnology market
- What are the key fundraising trends in the biotechnology market?
- What is the true size of the biotechnology market?
- The full range of business models in the biotechnology market
Who is the author of this content?
NEW MARKET PITCH TEAM
We track new markets so founders and investors can move fasterWe build living “market pitch” documents for emerging markets: from AI to synthetic biology and new proteins. Instead of digging through outdated PDFs, random blog posts, and hallucinated LLM answers, our clients get a clean, visual, always-updated view of what’s really happening. We map the key players, deals, regulations, metrics and signals that matter so you can decide faster whether a market is worth your time. Want to know more? Check out our about page. You can also follow us on Instagram or on Facebook.
How we created this content 🔎📝
At New Market Pitch, we kept seeing the same problem: when you look at a new market, the data is either missing, paywalled, or buried in 300-page reports that feel like they were written in the 80s. On the other side, LLMs and random blog posts give you confident answers with no sources, and sometimes they just make things up. That’s not good enough when you’re about to invest real money or launch a company.
So we decided to fix the experience. For each market we cover, we build a structured database and update it on a regular basis. We track funding rounds, fund memos, M&A moves, partnerships, new products, policy changes, and the real activity of startups and incumbents. Then we turn all of that into a clear “market pitch” that shows where the opportunities are and how people actually win in that space.
Every key data point is checked, sourced, and put back into context by our team. That’s how we can give you both speed and reliability: fast coverage of new markets, without the usual guesswork.